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    CAM7 calmodulin 7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823492, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAM7
    Official Full Name
    calmodulin 7
    Primary source
    TAIR:AT3G43810
    Locus tag
    AT3G43810
    See related
    Araport:AT3G43810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCAM7; calmodulin 7; CALMODULIN 7; Z-box Binding Factor 3; ZBF3
    Summary
    EF hand domain protein encodes a calmodulin. Can functionally complement a yeast CaM mutant.
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    Genomic context

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    See CAM7 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (15663000..15666469, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene zinc induced facilitator-like 2 Neighboring gene glutathione S-transferase tau 27 Neighboring gene miscRNA Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of Arabidopsis thaliana calmodulin7 and insight into its mode of DNA binding. Kumar S, et al. FEBS Lett, 2016 Sep. PMID 27500568
    2. The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis. Zeb Q, et al. J Integr Plant Biol, 2020 Jul. PMID 31755194
    3. Cell death suppressor Arabidopsis bax inhibitor-1 is associated with calmodulin binding and ion homeostasis. Ihara-Ohori Y, et al. Plant Physiol, 2007 Feb. PMID 17142482, Free PMC Article
    4. Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development. Kushwaha R, et al. Plant Cell, 2008 Jul. PMID 18621945, Free PMC Article
    5. Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8. Tidow H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Mar 1. PMID 20208181, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis.
      Title: The interaction of CaM7 and CNGC14 regulates root hair growth in Arabidopsis.
    2. We validated the model using biolayer interferometry, which confirmed that AtCaM7 interacts with Z-box DNA with high affinity
      Title: Crystal structure of Arabidopsis thaliana calmodulin7 and insight into its mode of DNA binding.
    3. CaM7 as a PEN3-interacting protein crucial to Arabidopsis Nonhost resistance (NHR) and emphasizes the importance of Ca(2+) sensing to plant immunity.
      Title: ABC transporter PEN3/PDR8/ABCG36 interacts with calmodulin that, like PEN3, is required for Arabidopsis nonhost resistance.
    4. Investigated the root phenotype of cam7 hy5 double mutants and showed that CAM7 and HY5 genetically interact to control the root growth. We have further shown an interdependent function of HY5 and CAM7 in abscisic acid responsiveness.
      Title: CAM7 and HY5 genetically interact to regulate root growth and abscisic acid responses.
    5. results demonstrate that CAM7 and HY5 directly interact with the HY5 promoter to mediate the transcriptional activity of HY5 during Arabidopsis seedling development
      Title: Arabidopsis CAM7 and HY5 physically interact and directly bind to the HY5 promoter to regulate its expression and thereby promote photomorphogenesis.
    6. complex between calmodulin and the regulatory domain of the plasma-membrane Ca(2+)-ATPase ACA8 from Arabidopsis has been crystallized. Crystals belonged to space group C2, with unit-cell parameters a = 176.8, b = 70.0, c = 69.8 A, beta = 113.2 degrees.
      Title: Expression, purification, crystallization and preliminary X-ray analysis of calmodulin in complex with the regulatory domain of the plasma-membrane Ca2+-ATPase ACA8.
    7. Data show that there is a concerted function of CAM7 and HY5 basic leucine zipper transcription factor in Arabidopsis seedling development.
      Title: Calmodulin7 plays an important role as transcriptional regulator in Arabidopsis seedling development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001339108.1
    NM_001339109.1
    NM_114249.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of photomorphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calmodulin 7
    NP_189967.1
    • calmodulin 7 (CAM7); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion, calcium-mediated signaling, regulation of photomorphogenesis; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand-like domain (InterPro:IPR011992), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin 5 (TAIR:AT2G27030.3); Has 33955 Blast hits to 23167 proteins in 1763 species: Archae - 4; Bacteria - 223; Metazoa - 14467; Fungi - 7347; Plants - 6966; Viruses - 0; Other Eukaryotes - 4948 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      15663000..15666469 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339107.1 → NP_001326523.1  calmodulin 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPJ2, A0A7G2EN73

    2. NM_114249.4 → NP_189967.1  calmodulin 7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_189967.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P59220
      UniProtKB/TrEMBL
      A0A178VGB3, A0A384LJK0, A8Y7S8, Q1H5F3
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 149
      PTZ00184; calmodulin; Provisional

    3. NM_001339108.1 → NP_001326524.1  calmodulin 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPJ1
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 113
      PTZ00184; calmodulin; Provisional

    4. NM_001339109.1 → NP_001326522.1  calmodulin 7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LPJ1
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 113
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59220.2

    Gene LinkOut

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