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    IPP1 isopentenyl diphosphate isomerase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 831505, updated on 18-Sep-2024

    Summary

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    Official Symbol
    IPP1
    Official Full Name
    isopentenyl diphosphate isomerase 1
    Primary source
    TAIR:AT5G16440
    Locus tag
    AT5G16440
    See related
    Araport:AT5G16440
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ISOPENTENYL DIPHOSPHATE ISOMERASE; isopentenyl diphosphate isomerase 1; MQK4.17; MQK4_17
    Summary
    Encodes a protein with isopentenyl diphosphate:dimethylallyl diphosphate isomerase activity. There is genetic evidence that it functions in the mevalonate, but not the MEP biosynthetic pathway.
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    Genomic context

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    See IPP1 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (5371627..5373809)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene Ribonuclease E inhibitor RraA/Dimethylmenaquinone methyltransferase Neighboring gene ncRNA Neighboring gene Defensin-like (DEFL) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal localization of Arabidopsis isopentenyl diphosphate isomerases suggests that part of the plant isoprenoid mevalonic acid pathway is compartmentalized to peroxisomes. Sapir-Mir M, et al. Plant Physiol, 2008 Nov. PMID 18988695, Free PMC Article
    2. The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis. Phillips MA, et al. Plant Cell, 2008 Mar. PMID 18319397, Free PMC Article
    3. Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis. Okada K, et al. Plant Cell Physiol, 2008 Apr. PMID 18303110
    4. Analysis of the isopentenyl diphosphate isomerase gene family from Arabidopsis thaliana. Campbell M, et al. Plant Mol Biol, 1998 Jan. PMID 9484444
    5. The Arabidopsis Proteins AtNHR2A and AtNHR2B Are Multi-Functional Proteins Integrating Plant Immunity With Other Biological Processes. Singh R, et al. Front Plant Sci, 2020. PMID 32194606, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Each of Arabidopsis IPP2 and IPP1 isomerases is found in multiple but partially overlapping subcellular locations, and each can compensate for the loss of the other through partial redundancy in the cytosol.
      Title: The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis.
    2. IPI plays a critical role in isoprenoid biosynthesis via the MVA pathway, and IPI is essential for the maintenance of appropriate levels of IPP and DMAPP in different subcellular compartments in plants. [IPI1]
      Title: Genetic evidence for the role of isopentenyl diphosphate isomerases in the mevalonate pathway and plant development in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_121649.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables isopentenyl-diphosphate delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isopentenyl-diphosphate delta-isomerase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chlorophyll biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chlorophyll biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in dimethylallyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within isopentenyl diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within isoprenoid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid HDA PubMed 
    located_in plastid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    isopentenyl diphosphate isomerase 1
    NP_197148.3
    • isopentenyl diphosphate isomerase 1 (IPP1); FUNCTIONS IN: isopentenyl-diphosphate delta-isomerase activity; INVOLVED IN: chlorophyll biosynthetic process, isoprenoid biosynthetic process, isopentenyl diphosphate biosynthetic process; LOCATED IN: cytosol, chloroplast, plastid; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: NUDIX hydrolase domain-like (InterPro:IPR015797), NUDIX hydrolase domain (InterPro:IPR000086), Isopentenyl-diphosphate delta-isomerase, type 1 (InterPro:IPR011876); BEST Arabidopsis thaliana protein match is: isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase 2 (TAIR:AT3G02780.1); Has 2226 Blast hits to 2225 proteins in 801 species: Archae - 35; Bacteria - 1199; Metazoa - 210; Fungi - 137; Plants - 180; Viruses - 0; Other Eukaryotes - 465 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      5371627..5373809
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_121649.6 → NP_197148.3  isopentenyl diphosphate isomerase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_197148.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38929, Q42552, Q9FFE1
      UniProtKB/TrEMBL
      A0A178ULI3, A0A5S9Y4N3
      Conserved Domains (1) summary
      PLN02552
      Location:58 → 291
      PLN02552; isopentenyl-diphosphate delta-isomerase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38929.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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