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    HGO homogentisate 1,2-dioxygenase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 835494, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HGO
    Official Full Name
    homogentisate 1,2-dioxygenase
    Primary source
    TAIR:AT5G54080
    Locus tag
    AT5G54080
    See related
    Araport:AT5G54080
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    2-dioxygenase; 2-DIOXYGENASE; AtHGO; homogentisate 1; HOMOGENTISATE 1; MJP23.6; MJP23_6
    Summary
    Encodes a homogentisate 1,2-dioxygenase that can convert homogentisate to malylacetoacetate and is likely to be involved in tyrosine catabolism.
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    Genomic context

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    See HGO in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    10
    Sequence:
    Chromosome: 5; NC_003076.8 (21945865..21948913)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene B3 domain protein Neighboring gene heat shock transcription factor A9 Neighboring gene ncRNA Neighboring gene DNA mismatch repair protein MutS, type 2 Neighboring gene proteoglycan-like protein Neighboring gene SPFH/Band 7/PHB domain-containing membrane-associated protein family

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of fumarylacetoacetate hydrolase causes spontaneous cell death under short-day conditions in Arabidopsis. Han C, et al. Plant Physiol, 2013 Aug. PMID 23743712, Free PMC Article
    2. Enzymes of tyrosine catabolism in Arabidopsis thaliana. Dixon DP, et al. Plant Sci, 2006 Sep. PMID 22980205
    3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
    4. Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana. Tabata S, et al. Nature, 2000 Dec 14. PMID 11130714

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    NM_124787.4
    NM_180856.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables homogentisate 1,2-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within homogentisate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within tyrosine catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    homogentisate 1,2-dioxygenase
    NP_200219.1
    • ''homogentisate 1,2-dioxygenase'' (HGO); FUNCTIONS IN: homogentisate 1,2-dioxygenase activity; INVOLVED IN: oxidation reduction, tyrosine metabolic process, L-phenylalanine catabolic process, tyrosine catabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cupin, RmlC-type (InterPro:IPR011051), Homogentisate 1,2-dioxygenase (InterPro:IPR005708); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).
    NP_851187.1
    • ''homogentisate 1,2-dioxygenase'' (HGO); FUNCTIONS IN: homogentisate 1,2-dioxygenase activity; INVOLVED IN: tyrosine metabolic process, oxidation reduction, L-phenylalanine catabolic process, tyrosine catabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cupin, RmlC-type (InterPro:IPR011051), Homogentisate 1,2-dioxygenase (InterPro:IPR005708); Has 1765 Blast hits to 1763 proteins in 704 species: Archae - 21; Bacteria - 1187; Metazoa - 139; Fungi - 155; Plants - 44; Viruses - 0; Other Eukaryotes - 219 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      21945865..21948913
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_124787.4 → NP_200219.1  homogentisate 1,2-dioxygenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200219.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L9I0, Q9LDB8, Q9ZRA2
      UniProtKB/TrEMBL
      A0A178UDA7
      Conserved Domains (1) summary
      PLN02658
      Location:13 → 446
      PLN02658; homogentisate 1,2-dioxygenase

    2. NM_180856.4 → NP_851187.1  homogentisate 1,2-dioxygenase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_851187.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8L9I0, Q9LDB8, Q9ZRA2
      UniProtKB/TrEMBL
      A0A178UDA7
      Conserved Domains (1) summary
      PLN02658
      Location:13 → 446
      PLN02658; homogentisate 1,2-dioxygenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZRA2.2

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