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    RD21A Granulin repeat cysteine protease family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841122, updated on 18-Sep-2024

    Summary

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    Official Symbol
    RD21A
    Official Full Name
    Granulin repeat cysteine protease family protein
    Primary source
    TAIR:AT1G47128
    Locus tag
    AT1G47128
    See related
    Araport:AT1G47128
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F2G19.31; F2G19_31; RD21; responsive to dehydration 21; responsive to dehydration 21A; RESPONSIVE TO DEHYDRATION 21A
    Summary
    cysteine proteinase precursor-like protein/ dehydration stress-responsive gene (RD21). Has been shown to have peptide ligase activity and protease activity in vitro. RD21 is involved in immunity to the necrotrophic fungal pathogen Botrytis cinerea.
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    Genomic context

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    See RD21A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (17282749..17285749, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene VIER F-box protein 1 Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protist ubiquitin ligase effector PbE3-2 targets cysteine protease RD21A to impede plant immunity. Li C, et al. Plant Physiol, 2024 Feb 29. PMID 38035763
    2. A root-knot nematode effector targets the Arabidopsis cysteine protease RD21A for degradation to suppress plant defense and promote parasitism. Yu J, et al. Plant J, 2024 Jun. PMID 38516730
    3. Activity profiling of papain-like cysteine proteases in plants. van der Hoorn RA, et al. Plant Physiol, 2004 Jul. PMID 15266051, Free PMC Article
    4. Re-targeting of a plant defense protease by a cyst nematode effector. Pogorelko GV, et al. Plant J, 2019 Jun. PMID 30801789
    5. A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14. Shindo T, et al. PLoS One, 2012. PMID 22238602, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A root-knot nematode effector targets the Arabidopsis cysteine protease RD21A for degradation to suppress plant defense and promote parasitism.
      Title: A root-knot nematode effector targets the Arabidopsis cysteine protease RD21A for degradation to suppress plant defense and promote parasitism.
    2. Protist ubiquitin ligase effector PbE3-2 targets cysteine protease RD21A to impede plant immunity.
      Title: Protist ubiquitin ligase effector PbE3-2 targets cysteine protease RD21A to impede plant immunity.
    3. The study shows that 4E02 removes RD21A from its defense-inducing pathway and repurposes this enzyme by targeting the active protease to different cell compartments.
      Title: Re-targeting of a plant defense protease by a cyst nematode effector.
    4. Serpin1 and WSCP differentially regulate the activity of RD21 during plant development in Arabidopsis thaliana.
      Title: Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana.
    5. WSCP physically interacts with RD21 and this interaction in turn inhibits the activity of RD21 as a pro-death protein. The regulatory circuit identified depends on the restricted expression of WSCP in the transmitting tract and the septum epidermis.
      Title: A Kunitz-type protease inhibitor regulates programmed cell death during flower development in Arabidopsis thaliana.
    6. AtSerpin1 and RD21 can modulate necrotroph-induced cell death.
      Title: Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis.
    7. RD21 causes a dominant protease activity in Arabidopsis leaf extracts, responsible for SDS-induced proteome degradation
      Title: Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana.
    8. RD21 provides immunity to a necrotrophic pathogen.
      Title: A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_103612.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type peptidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apoplast HDA PubMed 
    located_in cytoplasm IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plasma membrane IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 
    located_in secretory vesicle HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    Granulin repeat cysteine protease family protein
    NP_564497.1
    • responsive to dehydration 21 (RD21); FUNCTIONS IN: cysteine-type endopeptidase activity, cysteine-type peptidase activity; INVOLVED IN: response to water deprivation; LOCATED IN: apoplast, chloroplast, vacuole; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase C1A, papain (InterPro:IPR013128), Proteinase inhibitor I29, cathepsin propeptide (InterPro:IPR013201), Granulin (InterPro:IPR000118), Peptidase C1A, papain C-terminal (InterPro:IPR000668), Peptidase, cysteine peptidase active site (InterPro:IPR000169); BEST Arabidopsis thaliana protein match is: Granulin repeat cysteine protease family protein (TAIR:AT5G43060.1); Has 8846 Blast hits to 8044 proteins in 757 species: Archae - 51; Bacteria - 244; Metazoa - 4223; Fungi - 6; Plants - 1942; Viruses - 134; Other Eukaryotes - 2246 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      17282749..17285749 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_103612.3 → NP_564497.1  Granulin repeat cysteine protease family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564497.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P43297
      UniProtKB/TrEMBL
      A0A178WIH7, A0A5S9WMD8, Q94BX1
      Conserved Domains (3) summary
      smart00277
      Location:376 → 432
      GRAN; Granulin
      smart00848
      Location:50 → 107
      Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
      pfam00112
      Location:137 → 352
      Peptidase_C1; Papain family cysteine protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43297.1

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