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    2610042L04Rik RIKEN cDNA 2610042L04 gene [ Mus musculus (house mouse) ]

    Gene ID: 554327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    2610042L04Rikprovided by MGI
    Official Full Name
    RIKEN cDNA 2610042L04 geneprovided by MGI
    Primary source
    MGI:MGI:1914305
    See related
    Ensembl:ENSMUSG00000079388 AllianceGenome:MGI:1914305
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tksn; takusan
    Summary
    Acts upstream of or within several processes, including negative regulation of protein phosphorylation; regulation of synaptic activity; and synapse assembly. Is expressed in several structures, including ganglia; hypothalamus; sensory organ; smooth muscle tissue; and submandibular gland primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E18 (RPKM 4.3), whole brain E14.5 (RPKM 2.9) and 18 other tissues See more
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    Genomic context

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    See 2610042L04Rik in Genome Data Viewer
    Location:
    14 A2; 14 2.36 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (18115086..18135894, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (4333878..4354687)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3164 Neighboring gene predicted gene 3159 Neighboring gene predicted gene 3138 Neighboring gene predicted gene 2974

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. Nakanishi N, et al. J Neurosci, 2013 Aug 28. PMID 23986251, Free PMC Article
    2. Genome-wide analysis of gene transcription in the hypothalamus. Bischof JM, et al. Physiol Genomics, 2005 Jul 14. PMID 15870395
    3. Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Mu X, et al. Development, 2004 Mar. PMID 14973295
    4. Takusan: a large gene family that regulates synaptic activity. Tu S, et al. Neuron, 2007 Jul 5. PMID 17610818, Free PMC Article
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of synaptic activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC554327
    Names
    alpha42-takusan
    alpha46-takusan

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309398.1 → NP_001296327.1  uncharacterized protein LOC554327

      See identical proteins and their annotated locations for NP_001296327.1

      Status: VALIDATED

      Source sequence(s)
      AC188088, AK011748
      Consensus CDS
      CCDS84074.1
      UniProtKB/TrEMBL
      A6NAV3, Q9D073
      Related
      ENSMUSP00000132127.2, ENSMUST00000165466.8
      Conserved Domains (1) summary
      pfam04822
      Location:1 → 73
      Takusan

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      18115086..18135894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247891.2 → XP_030103751.1  uncharacterized protein LOC554327 isoform X10

      UniProtKB/TrEMBL
      A6NAV3, Q9D073
      Conserved Domains (1) summary
      pfam04822
      Location:1 → 73
      Takusan

    2. XM_017316095.3 → XP_017171584.1  uncharacterized protein LOC554327 isoform X10

      UniProtKB/TrEMBL
      A6NAV3, Q9D073
      Conserved Domains (1) summary
      pfam04822
      Location:1 → 73
      Takusan

    3. XM_030247892.2 → XP_030103752.1  uncharacterized protein LOC554327 isoform X11

    4. XM_017316091.3 → XP_017171580.1  uncharacterized protein LOC554327 isoform X6

    5. XM_017316092.3 → XP_017171581.1  uncharacterized protein LOC554327 isoform X7

    6. XM_017316090.2 → XP_017171579.1  uncharacterized protein LOC554327 isoform X5

    7. XM_017316094.2 → XP_017171583.1  uncharacterized protein LOC554327 isoform X9

    8. XM_017316093.2 → XP_017171582.1  uncharacterized protein LOC554327 isoform X8

    9. XM_036158764.1 → XP_036014657.1  uncharacterized protein LOC554327 isoform X3

    10. XM_017316089.2 → XP_017171578.1  uncharacterized protein LOC554327 isoform X4

    11. XM_017316088.3 → XP_017171577.1  uncharacterized protein LOC554327 isoform X2

    12. XM_017316087.3 → XP_017171576.1  uncharacterized protein LOC554327 isoform X1

    RNA

    1. XR_874067.4 RNA Sequence

    2. XR_004938417.1 RNA Sequence

    3. XR_874065.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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