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    Mettl6 methyltransferase 6, tRNA N3-cytidine [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290564, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mettl6provided by RGD
    Official Full Name
    methyltransferase 6, tRNA N3-cytidineprovided by RGD
    Primary source
    RGD:1359565
    See related
    EnsemblRapid:ENSRNOG00000089254 AllianceGenome:RGD:1359565
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity and tRNA (cytidine-3-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be located in cytoplasm and nucleus. Orthologous to human METTL6 (methyltransferase 6, tRNA N3-cytidine). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 133.9), Spleen (RPKM 83.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mettl6 in Genome Data Viewer
    Location:
    16p16
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (6667971..6705385, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (6683820..6699013, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (7559964..7588841, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134482448 Neighboring gene SH3-domain binding protein 5 Neighboring gene uncharacterized LOC134482449 Neighboring gene ELL associated factor 1 Neighboring gene collagen like tail subunit of asymmetric acetylcholinesterase Neighboring gene uncharacterized LOC134482450 Neighboring gene 2-hydroxyacyl-CoA lyase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits. Niu J, et al. Am J Med Genet B Neuropsychiatr Genet, 2022 Apr. PMID 35591810
    2. Three distinct 3-methylcytidine (m(3)C) methyltransferases modify tRNA and mRNA in mice and humans. Xu L, et al. J Biol Chem, 2017 Sep 1. PMID 28655767, Free PMC Article
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
      Title: Mechanism of METTL3-mediated m6A modification in depression-induced cognitive deficits.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC94452

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-3-)-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tRNA N(3)-methylcytidine methyltransferase METTL6
    Names
    methyltransferase 6, methylcytidine
    methyltransferase like 6
    methyltransferase-like protein 6
    NP_001007624.1
    XP_006252644.1
    XP_006252645.1
    XP_008769210.1
    XP_038950196.1
    XP_038950197.1
    XP_063131206.1
    XP_063131207.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007623.1 → NP_001007624.1  tRNA N(3)-methylcytidine methyltransferase METTL6

      See identical proteins and their annotated locations for NP_001007624.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079309
      UniProtKB/Swiss-Prot
      Q6AXU8
      UniProtKB/TrEMBL
      A0A8I6GE72, A6KFY8, A6KFY9
      Related
      ENSRNOP00000074466.1, ENSRNOT00000084645.3
      Conserved Domains (2) summary
      COG2227
      Location:29 → 238
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      6667971..6705385 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275136.1 → XP_063131206.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X4

    2. XM_039094269.2 → XP_038950197.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

      UniProtKB/TrEMBL
      A6KFZ0
      Conserved Domains (2) summary
      COG2227
      Location:29 → 124
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam08242
      Location:84 → 177
      Methyltransf_12; Methyltransferase domain

    3. XM_006252582.5 → XP_006252644.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

      See identical proteins and their annotated locations for XP_006252644.1

      Conserved Domains (2) summary
      COG0500
      Location:35 → 298
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84 → 184
      Methyltransf_12; Methyltransferase domain

    4. XM_063275137.1 → XP_063131207.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X5

      UniProtKB/TrEMBL
      A6KFZ0

    5. XM_039094268.2 → XP_038950196.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X2

      UniProtKB/Swiss-Prot
      Q6AXU8
      UniProtKB/TrEMBL
      A0A8I6GE72, A6KFY8, A6KFY9
      Related
      ENSRNOP00000086596.1, ENSRNOT00000104042.2
      Conserved Domains (2) summary
      COG2227
      Location:29 → 238
      UbiG; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]
      pfam08242
      Location:84 → 182
      Methyltransf_12; Methyltransferase domain

    6. XM_006252583.5 → XP_006252645.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X1

      See identical proteins and their annotated locations for XP_006252645.1

      Conserved Domains (2) summary
      COG0500
      Location:35 → 298
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84 → 184
      Methyltransf_12; Methyltransferase domain

    7. XM_008770988.4 → XP_008769210.1  tRNA N(3)-methylcytidine methyltransferase METTL6 isoform X3

      Conserved Domains (2) summary
      COG0500
      Location:35 → 184
      SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
      pfam08242
      Location:84 → 184
      Methyltransf_12; Methyltransferase domain

    RNA

    1. XR_005494554.2 RNA Sequence

    2. XR_005494553.2 RNA Sequence

    3. XR_005494555.2 RNA Sequence

    4. XR_010058283.1 RNA Sequence

    5. XR_005494556.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AXU8.1 GenPept UniProtKB/Swiss-Prot:Q6AXU8

    Gene LinkOut

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