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    Zbtb11 zinc finger and BTB domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304010, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zbtb11provided by RGD
    Official Full Name
    zinc finger and BTB domain containing 11provided by RGD
    Primary source
    RGD:1308275
    See related
    EnsemblRapid:ENSRNOG00000001613 AllianceGenome:RGD:1308275
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 69. Orthologous to human ZBTB11 (zinc finger and BTB domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 139.1), Spleen (RPKM 125.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zbtb11 in Genome Data Viewer
    Location:
    11q12
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (58061355..58121768, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (44598694..44652559, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (47079201..47113993, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene SUMO specific peptidase 7 Neighboring gene uncharacterized LOC120095650 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit Neighboring gene PEST proteolytic signal containing nuclear protein Neighboring gene small nucleolar RNA SNORA29 Neighboring gene G protein subunit gamma 5, pseudogene 4 Neighboring gene zinc finger and BTB domain containing 11, opposite strand 1 Neighboring gene uncharacterized LOC134481067 Neighboring gene ribosomal protein L24 Neighboring gene centrosomal protein 97

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107097.1 → NP_001100567.1  zinc finger and BTB domain-containing protein 11

      Status: PROVISIONAL

      Source sequence(s)
      CH473967
      UniProtKB/TrEMBL
      A6IQQ6, D3ZDP9
      Related
      ENSRNOP00000031654.4, ENSRNOT00000034940.6
      Conserved Domains (7) summary
      PRK12387
      Location:556 → 621
      PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
      COG5048
      Location:666 → 839
      COG5048; FOG: Zn-finger [General function prediction only]
      COG5189
      Location:669 → 754
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:680 → 700
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18202
      Location:195 → 312
      BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
      pfam13465
      Location:899 → 922
      zf-H2C2_2; Zinc-finger double domain
      pfam17921
      Location:68 → 120
      Integrase_H2C2; Integrase zinc binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      58061355..58121768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088374.2 → XP_038944302.1  zinc finger and BTB domain-containing protein 11 isoform X1

      Conserved Domains (6) summary
      PRK12387
      Location:556 → 621
      PRK12387; formate hydrogenlyase complex iron-sulfur subunit; Provisional
      COG5048
      Location:695 → 801
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:680 → 700
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18202
      Location:195 → 312
      BTB_POZ_ZBTB11; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11)
      pfam13465
      Location:939 → 962
      zf-H2C2_2; Zinc-finger double domain
      pfam17921
      Location:68 → 120
      Integrase_H2C2; Integrase zinc binding domain

    RNA

    1. XR_005491031.2 RNA Sequence

    2. XR_010055958.1 RNA Sequence

    3. XR_010055957.1 RNA Sequence

    4. XR_010055956.1 RNA Sequence

    5. XR_005491033.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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