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    Uqcc4 ubiquinol-cytochrome c reductase complex assembly factor 4 [ Mus musculus (house mouse) ]

    Gene ID: 214489, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Uqcc4provided by MGI
    Official Full Name
    ubiquinol-cytochrome c reductase complex assembly factor 4provided by MGI
    Primary source
    MGI:MGI:2670966
    See related
    Ensembl:ENSMUSG00000067722 AllianceGenome:MGI:2670966
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccsmst1
    Summary
    Involved in mitochondrial respiratory chain complex III assembly. Located in mitochondrial inner membrane. Orthologous to human UQCC4 (ubiquinol-cytochrome c reductase complex assembly factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.3), adrenal adult (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Uqcc4 in Genome Data Viewer
    Location:
    17 A3.3; 17 12.53 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25403535..25406636)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25184561..25187662)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene chloride channel, voltage-sensitive 7 Neighboring gene microRNA 12188 Neighboring gene coiled-coil domain containing 154 Neighboring gene intestine-critical region regulatory element Neighboring gene proline and glutamate rich with coiled coil 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:25321285-25321526 Neighboring gene predicted gene, 52286 Neighboring gene unkempt family like zinc finger Neighboring gene N-acetylglucosamine-1-phosphotransferase, gamma subunit Neighboring gene TSR3 20S rRNA accumulation

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. Liang C, et al. Cell Rep, 2022 Aug 16. PMID 35977508
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7403

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial respiratory chain complex III assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquinol-cytochrome c reductase complex assembly factor 4
    Names
    protein CCSMST1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_183150.2 → NP_898973.2  ubiquinol-cytochrome c reductase complex assembly factor 4 precursor

      See identical proteins and their annotated locations for NP_898973.2

      Status: VALIDATED

      Source sequence(s)
      AC130711, BC094389, BY262222
      Consensus CDS
      CCDS57057.1
      UniProtKB/Swiss-Prot
      Q6RUT7
      Related
      ENSMUSP00000137122.2, ENSMUST00000088307.5
      Conserved Domains (2) summary
      pfam04697
      Location:7 → 61
      Pinin_SDK_N; pinin/SDK conserved region
      pfam15013
      Location:49 → 111
      CCSMST1; CCSMST1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25403535..25406636
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6RUT7.1 GenPept UniProtKB/Swiss-Prot:Q6RUT7

    Gene LinkOut

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