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    Cfap100 cilia and flagella associated protein 100 [ Mus musculus (house mouse) ]

    Gene ID: 243538, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cfap100provided by MGI
    Official Full Name
    cilia and flagella associated protein 100provided by MGI
    Primary source
    MGI:MGI:2141635
    See related
    Ensembl:ENSMUSG00000048794 AllianceGenome:MGI:2141635
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ccdc37; C030041G11Rik; C230069K22Rik
    Summary
    Predicted to enable dynein complex binding activity. Predicted to be involved in cilium movement and inner dynein arm assembly. Predicted to be located in axonemal doublet microtubule and motile cilium. Predicted to be active in ciliary basal body. Is expressed in central nervous system and nose. Orthologous to human CFAP100 (cilia and flagella associated protein 100). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 13.0), CNS E18 (RPKM 2.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cfap100 in Genome Data Viewer
    Location:
    6 D1; 6 40.16 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (90380713..90412379, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (90403731..90429768, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene urocanase domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E10392 Neighboring gene STARR-seq mESC enhancer starr_16614 Neighboring gene STARR-seq mESC enhancer starr_16615 Neighboring gene ZXD family zinc finger C Neighboring gene predicted gene, 53295 Neighboring gene STARR-seq mESC enhancer starr_16619 Neighboring gene Kruppel-like transcription factor 15 Neighboring gene STARR-seq mESC enhancer starr_16625 Neighboring gene STARR-seq mESC enhancer starr_16627 Neighboring gene aldehyde dehydrogenase 1 family, member L1 Neighboring gene predicted gene 15756

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identifying new candidate genes for hereditary facial paresis on chromosome 3q21-q22 by RNA in situ hybridization in mouse. van der Zwaag B, et al. Genomics, 2005 Jul. PMID 15953540
    2. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    3. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in inner dynein arm assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal doublet microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in motile cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    cilia- and flagella-associated protein 100
    Names
    coiled-coil domain containing 37
    coiled-coil domain-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173775.3 → NP_776136.2  cilia- and flagella-associated protein 100

      Status: VALIDATED

      Source sequence(s)
      AC163346
      Consensus CDS
      CCDS51849.1
      UniProtKB/Swiss-Prot
      E9PYA2, Q6AXD6, Q80VN0
      Related
      ENSMUSP00000126515.2, ENSMUST00000165673.5
      Conserved Domains (1) summary
      pfam13863
      Location:154 → 272
      DUF4200; Domain of unknown function (DUF4200)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      90380713..90412379 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241338.4 → XP_011239640.1  cilia- and flagella-associated protein 100 isoform X1

      See identical proteins and their annotated locations for XP_011239640.1

      Conserved Domains (1) summary
      pfam13863
      Location:154 → 272
      DUF4200; Domain of unknown function (DUF4200)

    2. XM_030255376.2 → XP_030111236.1  cilia- and flagella-associated protein 100 isoform X7

      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    3. XM_017321584.3 → XP_017177073.1  cilia- and flagella-associated protein 100 isoform X1

      Conserved Domains (1) summary
      pfam13863
      Location:154 → 272
      DUF4200; Domain of unknown function (DUF4200)

    4. XM_030255375.2 → XP_030111235.1  cilia- and flagella-associated protein 100 isoform X6

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    5. XM_006506095.5 → XP_006506158.1  cilia- and flagella-associated protein 100 isoform X5

      See identical proteins and their annotated locations for XP_006506158.1

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    6. XM_030255377.2 → XP_030111237.1  cilia- and flagella-associated protein 100 isoform X8

      UniProtKB/TrEMBL
      A0A171EBL0
      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    7. XM_030255373.2 → XP_030111233.1  cilia- and flagella-associated protein 100 isoform X4

      Conserved Domains (1) summary
      pfam13863
      Location:127 → 245
      DUF4200; Domain of unknown function (DUF4200)

    8. XM_011241340.3 → XP_011239642.1  cilia- and flagella-associated protein 100 isoform X3

      Conserved Domains (1) summary
      pfam13863
      Location:127 → 245
      DUF4200; Domain of unknown function (DUF4200)

    9. XM_011241339.4 → XP_011239641.1  cilia- and flagella-associated protein 100 isoform X2

      Conserved Domains (1) summary
      pfam13863
      Location:153 → 271
      DUF4200; Domain of unknown function (DUF4200)

    10. XM_030255374.2 → XP_030111234.1  cilia- and flagella-associated protein 100 isoform X6

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    11. XM_030255378.2 → XP_030111238.1  cilia- and flagella-associated protein 100 isoform X8

      UniProtKB/TrEMBL
      A0A171EBL0
      Related
      ENSMUSP00000059976.6, ENSMUST00000062750.12
      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    12. XM_030255372.2 → XP_030111232.1  cilia- and flagella-associated protein 100 isoform X1

      Conserved Domains (1) summary
      pfam13863
      Location:154 → 272
      DUF4200; Domain of unknown function (DUF4200)

    13. XM_036166116.1 → XP_036022009.1  cilia- and flagella-associated protein 100 isoform X9

      Conserved Domains (1) summary
      pfam13863
      Location:14 → 66
      DUF4200; Domain of unknown function (DUF4200)

    14. XM_030255384.2 → XP_030111244.1  cilia- and flagella-associated protein 100 isoform X10

      Conserved Domains (1) summary
      pfam13863
      Location:14 → 66
      DUF4200; Domain of unknown function (DUF4200)

    15. XM_011241341.4 → XP_011239643.1  cilia- and flagella-associated protein 100 isoform X5

      See identical proteins and their annotated locations for XP_011239643.1

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    16. XM_036166115.1 → XP_036022008.1  cilia- and flagella-associated protein 100 isoform X8

      UniProtKB/TrEMBL
      A0A171EBL0
      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    17. XM_011241342.4 → XP_011239644.1  cilia- and flagella-associated protein 100 isoform X5

      See identical proteins and their annotated locations for XP_011239644.1

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    18. XM_036166113.1 → XP_036022006.1  cilia- and flagella-associated protein 100 isoform X7

      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    19. XM_036166112.1 → XP_036022005.1  cilia- and flagella-associated protein 100 isoform X5

      Conserved Domains (1) summary
      pfam13863
      Location:92 → 210
      DUF4200; Domain of unknown function (DUF4200)

    20. XM_036166117.1 → XP_036022010.1  cilia- and flagella-associated protein 100 isoform X9

      Conserved Domains (1) summary
      pfam13863
      Location:14 → 66
      DUF4200; Domain of unknown function (DUF4200)

    21. XM_011241348.1 → XP_011239650.1  cilia- and flagella-associated protein 100 isoform X9

      See identical proteins and their annotated locations for XP_011239650.1

      Conserved Domains (1) summary
      pfam13863
      Location:14 → 66
      DUF4200; Domain of unknown function (DUF4200)

    22. XM_036166118.1 → XP_036022011.1  cilia- and flagella-associated protein 100 isoform X9

      Conserved Domains (1) summary
      pfam13863
      Location:14 → 66
      DUF4200; Domain of unknown function (DUF4200)

    23. XM_036166114.1 → XP_036022007.1  cilia- and flagella-associated protein 100 isoform X7

      Conserved Domains (1) summary
      pfam13863
      Location:1 → 118
      DUF4200; Domain of unknown function (DUF4200)

    RNA

    1. XR_003956196.2 RNA Sequence

    2. XR_001785131.3 RNA Sequence

    3. XR_001785132.3 RNA Sequence

    4. XR_001785130.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80VN0.2 GenPept UniProtKB/Swiss-Prot:Q80VN0

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