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    Fbxl12 F-box and leucine-rich repeat protein 12 [ Mus musculus (house mouse) ]

    Gene ID: 30843, updated on 13-Jan-2025

    Summary

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    Official Symbol
    Fbxl12provided by MGI
    Official Full Name
    F-box and leucine-rich repeat protein 12provided by MGI
    Primary source
    MGI:MGI:1354738
    See related
    Ensembl:ENSMUSG00000066892 AllianceGenome:MGI:1354738
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fbl12; 3110048D16Rik
    Summary
    Acts upstream of or within ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of ubiquitin ligase complex. Is expressed in chorioallantoic placenta; decidua; and embryo. Orthologous to human FBXL12 (F-box and leucine rich repeat protein 12). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in thymus adult (RPKM 77.7), spleen adult (RPKM 18.9) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fbxl12 in Genome Data Viewer
    Location:
    9 A3; 9 7.59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20549045..20556064, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20637749..20644768, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6716 Neighboring gene predicted gene, 51704 Neighboring gene zinc finger protein 846 Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene ubiquitin-like 5 Neighboring gene peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FBXL12 regulates T-cell differentiation in a cell-autonomous manner. Nita A, et al. Genes Cells, 2016 May. PMID 26999371
    2. Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12. Zhao B, et al. Nat Immunol, 2019 Oct. PMID 31451788, Free PMC Article
    3. Fbxl12 triggers G1 arrest by mediating degradation of calmodulin kinase I. Mallampalli RK, et al. Cell Signal, 2013 Oct. PMID 23707388, Free PMC Article
    4. FBXL12-Mediated Degradation of ALDH3 is Essential for Trophoblast Differentiation During Placental Development. Nishiyama M, et al. Stem Cells, 2015 Nov. PMID 26124079
    5. A family of mammalian F-box proteins. Winston JT, et al. Curr Biol, 1999 Oct 21. PMID 10531037

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (3)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box/LRR-repeat protein 12
    Names
    F-box protein FBL12
    F-box protein containing leucine repeats 12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002846.2 → NP_001002846.1  F-box/LRR-repeat protein 12 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AK011081, AK030910, AK031262
      Consensus CDS
      CCDS22881.1
      UniProtKB/TrEMBL
      A0A0R4J1Q8
      Related
      ENSMUSP00000083649.4, ENSMUST00000086458.10
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_001286529.1 → NP_001273458.1  F-box/LRR-repeat protein 12 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate 5' structure and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform c, which has a longer and distinct N-terminus, compared to isoform a.
      Source sequence(s)
      AK011081, AK030910, AK031262, DN176232
      Consensus CDS
      CCDS90505.1
      UniProtKB/TrEMBL
      A0A0R4J1W2
      Related
      ENSMUSP00000121429.3, ENSMUST00000151861.9
      Conserved Domains (3) summary
      cd09293
      Location:144 → 249
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:127 → 148
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:51 → 73
      F-box-like; F-box-like

    3. NM_001286530.1 → NP_001273459.1  F-box/LRR-repeat protein 12 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. It encodes isoform b, which has a shorter N-terminus, compared to isoform a. Variants 2 and 4 encode the same protein.
      Source sequence(s)
      AK030910, AK031262, DN176232
      Consensus CDS
      CCDS22881.1
      UniProtKB/TrEMBL
      A0A0R4J1Q8
      Related
      ENSMUSP00000114466.3, ENSMUST00000140702.3
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]

    4. NM_013911.3 → NP_038939.2  F-box/LRR-repeat protein 12 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a.
      Source sequence(s)
      AC164565, AF313405, AI430452, AK030910, AK031262
      Consensus CDS
      CCDS22880.1
      UniProtKB/Swiss-Prot
      Q3UVH7, Q8CDX0, Q9CY04, Q9EPX5, Q9QZN5
      Related
      ENSMUSP00000083650.5, ENSMUST00000086459.6
      Conserved Domains (3) summary
      cd09293
      Location:121 → 226
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:104 → 125
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:4 → 48
      F-box-like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      20549045..20556064 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006510398.3 → XP_006510461.1  F-box/LRR-repeat protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1Q8
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. XM_006510397.3 → XP_006510460.1  F-box/LRR-repeat protein 12 isoform X1

      UniProtKB/Swiss-Prot
      Q3UVH7, Q8CDX0, Q9CY04, Q9EPX5, Q9QZN5
      Related
      ENSMUSP00000119124.2, ENSMUST00000148631.8
      Conserved Domains (3) summary
      cd09293
      Location:121 → 226
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:104 → 125
      LRR_AMN1; leucine-rich repeat [structural motif]
      pfam12937
      Location:4 → 48
      F-box-like

    3. XM_006510399.3 → XP_006510462.1  F-box/LRR-repeat protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A0R4J1Q8
      Conserved Domains (2) summary
      cd09293
      Location:68 → 173
      AMN1; Antagonist of mitotic exit network protein 1
      sd00034
      Location:51 → 72
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EPX5.1 GenPept UniProtKB/Swiss-Prot:Q9EPX5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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