Amigo2 adhesion molecule with Ig like domain 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amigo2provided by MGI
Official Full Name: adhesion molecule with Ig like domain 2provided by MGI
Primary source: MGI:MGI:2145995
See related: Ensembl:ENSMUSG00000048218 AllianceGenome:MGI:2145995
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ali1; AMIGO-2
Summary: Acts upstream of or within positive regulation of synapse assembly. Predicted to be located in nucleus and plasma membrane. Predicted to be active in membrane. Is expressed in several structures, including brain; branchial arch; cranial ganglion; genitourinary system; and retina. Orthologous to human AMIGO2 (adhesion molecule with Ig like domain 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in frontal lobe adult (RPKM 2.9), lung adult (RPKM 2.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 F1; 15 52.91 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (97141955..97145168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (97244074..97247287, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus.
Title: Adhesion molecule Amigo2 is involved in the fasciculation process of the fasciculus retroflexus.
AMIGO2 Scales Dendrite Arbors in the Retina.
Title: AMIGO2 Scales Dendrite Arbors in the Retina.
AMIGO2 deficiency plays an attenuated cardio-pro-tective role in ischemic heart disease via inactivation of the PDK1/Pten/Akt pathway.
Title: Loss of AMIGO2 causes dramatic damage to cardiac preservation after ischemic injury.
The authors report the identification of Amigo2 as a new mediator of invasion in breast cancer.
Title: Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo.
Amigo2, which is a member of the Amigo family that shows high species conservation, may be involved in determining liver metastasis by preferential adhesion of the tumour cells to liver endothelial cells.
Title: Amigo2-upregulation in Tumour Cells Facilitates Their Attachment to Liver Endothelial Cells Resulting in Liver Metastases.
AMG2KO mice exhibited ameliorated experimental autoimmune encephalomyelitis, dampened spinal T-cell accumulation, decreased serum IL-17A levels and enhanced splenic IL-10 production.
Title: AMIGO2 modulates T cell functions and its deficiency in mice ameliorates experimental autoimmune encephalomyelitis.
Report AMIGO2 mRNA expression in CA2/Ca3a hippocampal region of mouse brain.
Title: AMIGO2 mRNA expression in hippocampal CA2 and CA3a.
Expression of ali1 promotes depolarization-dependent survival of cerebellar granule neurons. Mouse ali1 mapped to a chromosome 15 locus syntenic to candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
Title: Alivin 1, a novel neuronal activity-dependent gene, inhibits apoptosis and promotes survival of cerebellar granule neurons.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

General gene information

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Markers

Amigo2 (e-PCR), detects polymorphism
- UniSTS:525535

AI415330 (e-PCR)
- UniSTS:160501

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in brain development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of synapse assembly	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: amphoterin-induced protein 2

Names: alivin 1; amphoterin induced gene and ORF 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164563.1 → NP_001158035.1 amphoterin-induced protein 2 precursor

See identical proteins and their annotated locations for NP_001158035.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC102914, AK038783

Consensus CDS

CCDS27780.1

UniProtKB/Swiss-Prot

Q80ZD9

UniProtKB/TrEMBL

Q4VBE6

Related

ENSMUSP00000059913.6, ENSMUST00000053106.7

Conserved Domains (5) summary

smart00410
Location:297 → 379

IG_like; Immunoglobulin like

cd00116
Location:70 → 203

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:50 → 71

LRR_RI; leucine-rich repeat [structural motif]

pfam00047
Location:297 → 367

ig; Immunoglobulin domain

pfam13855
Location:116 → 174

LRR_8; Leucine rich repeat
NM_001164602.1 → NP_001158074.1 amphoterin-induced protein 2 precursor

See identical proteins and their annotated locations for NP_001158074.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC102914, CK623441

Consensus CDS

CCDS27780.1

UniProtKB/Swiss-Prot

Q80ZD9

UniProtKB/TrEMBL

Q4VBE6

Conserved Domains (5) summary

smart00410
Location:297 → 379

IG_like; Immunoglobulin like

cd00116
Location:70 → 203

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:50 → 71

LRR_RI; leucine-rich repeat [structural motif]

pfam00047
Location:297 → 367

ig; Immunoglobulin domain

pfam13855
Location:116 → 174

LRR_8; Leucine rich repeat
NM_178114.4 → NP_835215.1 amphoterin-induced protein 2 precursor

See identical proteins and their annotated locations for NP_835215.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC102914, BC095990

Consensus CDS

CCDS27780.1

UniProtKB/Swiss-Prot

Q80ZD9

UniProtKB/TrEMBL

Q4VBE6

Related

ENSMUSP00000155019.2, ENSMUST00000229890.2

Conserved Domains (5) summary

smart00410
Location:297 → 379

IG_like; Immunoglobulin like

cd00116
Location:70 → 203

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:50 → 71

LRR_RI; leucine-rich repeat [structural motif]

pfam00047
Location:297 → 367

ig; Immunoglobulin domain

pfam13855
Location:116 → 174

LRR_8; Leucine rich repeat