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    Tepsin TEPSIN, adaptor related protein complex 4 accessory protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360673, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Tepsinprovided by RGD
    Official Full Name
    TEPSIN, adaptor related protein complex 4 accessory proteinprovided by RGD
    Primary source
    RGD:1307410
    See related
    EnsemblRapid:ENSRNOG00000028161 AllianceGenome:RGD:1307410
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Enthd2; RGD1307410
    Summary
    Located in coated vesicle membrane. Part of AP-4 adaptor complex. Orthologous to human TEPSIN (TEPSIN adaptor related protein complex 4 accessory protein). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 45.5), Spleen (RPKM 35.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tepsin in Genome Data Viewer
    Location:
    10q32.3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (105872363..105879731, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (105373939..105381310, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (109271161..109278745, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene centrosomal protein 131 Neighboring gene microRNA 3594 Neighboring gene microRNA 3562 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 8 Neighboring gene solute carrier family 38, member 10

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular Basis for the Interaction Between AP4 β4 and its Accessory Protein, Tepsin. Frazier MN, et al. Traffic, 2016 Apr. PMID 26756312, Free PMC Article
    2. Bivalent Motif-Ear Interactions Mediate the Association of the Accessory Protein Tepsin with the AP-4 Adaptor Complex. Mattera R, et al. J Biol Chem, 2015 Dec 25. PMID 26542808, Free PMC Article
    3. Multivariate proteomic profiling identifies novel accessory proteins of coated vesicles. Borner GH, et al. J Cell Biol, 2012 Apr 2. PMID 22472443, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of AP-4 adaptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in coated vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in coated vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in organelle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    AP-4 complex accessory subunit tepsin
    Names
    ENTH domain containing 2
    ENTH domain-containing protein 2
    tetra-epsin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100729.1 → NP_001094199.1  AP-4 complex accessory subunit tepsin

      Status: VALIDATED

      Source sequence(s)
      BC089956, JAXUCZ010000010
      UniProtKB/Swiss-Prot
      G3V8Y7, Q5EB78
      UniProtKB/TrEMBL
      A0A8L2QJ15
      Related
      ENSRNOP00000079089.1, ENSRNOT00000106724.2
      Conserved Domains (1) summary
      cd03572
      Location:16 → 134
      ENTH_like_Tepsin; Epsin N-Terminal Homology (ENTH)-like domain of AP-4 complex accessory subunit Tepsin and similar domains

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      105872363..105879731 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247895.5 → XP_006247957.1  AP-4 complex accessory subunit tepsin isoform X2

      UniProtKB/TrEMBL
      A0A8L2QJ15
      Conserved Domains (1) summary
      cd03572
      Location:13 → 125
      ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

    2. XM_006247894.5 → XP_006247956.1  AP-4 complex accessory subunit tepsin isoform X2

      UniProtKB/TrEMBL
      A0A8L2QJ15
      Conserved Domains (1) summary
      cd03572
      Location:13 → 125
      ENTH_epsin_related; ENTH domain, Epsin Related family; composed of hypothetical proteins containing an ENTH-like domain. The epsin N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in ...

    3. XM_039086442.2 → XP_038942370.1  AP-4 complex accessory subunit tepsin isoform X1

      UniProtKB/TrEMBL
      A0A8L2QJ15
      Related
      ENSRNOP00000096998.2, ENSRNOT00000099857.2
      Conserved Domains (1) summary
      cd03572
      Location:9 → 126
      ENTH_like_Tepsin; Epsin N-Terminal Homology (ENTH)-like domain of AP-4 complex accessory subunit Tepsin and similar domains
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3V8Y7.1 GenPept UniProtKB/Swiss-Prot:G3V8Y7

    Gene LinkOut

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