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    Evi5l ecotropic viral integration site 5-like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 304201, updated on 9-Dec-2024

    Summary

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    Symbol
    Evi5lprovided by RGD
    Full Name
    ecotropic viral integration site 5-likeprovided by RGD
    Primary source
    RGD:1561962
    See related
    EnsemblRapid:ENSRNOG00000001034 AllianceGenome:RGD:1561962
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1561962
    Summary
    Predicted to enable GTPase activator activity and small GTPase binding activity. Predicted to be involved in negative regulation of cilium assembly and positive regulation of GTPase activity. Orthologous to human EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 86.8), Kidney (RPKM 48.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Evi5l in Genome Data Viewer
    Location:
    12p12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (7317474..7356445)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (2519648..2558766)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (2588066..2626336, complement)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690865 Neighboring gene CD209f molecule Neighboring gene proline rich 36 Neighboring gene leucine rich repeat containing 8 VRAC subunit E

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of Rab GTPases involved in primary cilium formation. Yoshimura S, et al. J Cell Biol, 2007 Jul 30. PMID 17646400, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    EVI5-like protein; ecotropic viral integration site 5-like
    Names
    EVI5-like protein-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432039.1 → NP_001418968.1  ecotropic viral integration site 5-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2K1A4, D3ZXM4

    2. NM_001432040.1 → NP_001418969.1  ecotropic viral integration site 5-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A0G2JX24, D3ZXM4

    3. NM_001432041.1 → NP_001418970.1  ecotropic viral integration site 5-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A0A8I6AHD4, D3ZXM4

    4. NM_001432042.1 → NP_001418971.1  ecotropic viral integration site 5-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000012
      UniProtKB/TrEMBL
      A6KQ55, D3ZCJ7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      7317474..7356445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039089908.2 → XP_038945836.1  EVI5-like protein isoform X2

      Related
      ENSRNOP00000070107.2, ENSRNOT00000077396.3
      Conserved Domains (2) summary
      smart00164
      Location:117 → 325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:369 → 709
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    2. XM_039089907.2 → XP_038945835.1  EVI5-like protein isoform X1

      Related
      ENSRNOP00000071761.2, ENSRNOT00000079918.3
      Conserved Domains (2) summary
      smart00164
      Location:117 → 325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      TIGR02168
      Location:381 → 719
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_039089909.2 → XP_038945837.1  EVI5-like protein isoform X3

      Related
      ENSRNOP00000092619.1, ENSRNOT00000114920.2
      Conserved Domains (2) summary
      smart00164
      Location:117 → 325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      COG1196
      Location:357 → 691
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    4. XM_039089910.2 → XP_038945838.1  EVI5-like protein isoform X4

      Related
      ENSRNOP00000036774.7, ENSRNOT00000034124.8
      Conserved Domains (1) summary
      smart00164
      Location:117 → 325
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version

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