Galt Galactose-1-phosphate uridylyltransferase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Galtprovided by FlyBase
Official Full Name: Galactose-1-phosphate uridylyltransferaseprovided by FlyBase
Primary source: FLYBASE:FBgn0263200
Locus tag: Dmel_CG9232
See related: AllianceGenome:FB:FBgn0263200
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG9232; dGALT; Dmel\CG9232; GALT
Summary: Enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity. Involved in UDP-alpha-D-glucose metabolic process; UDP-galactose biosynthetic process; and galactose catabolic process via UDP-galactose. Predicted to be active in cytosol. Is expressed in several structures, including adult head; anterior endoderm; embryonic/larval midgut primordium; epithelium; and gut section. Used to study classic galactosemia and galactosemia. Human ortholog(s) of this gene implicated in classic galactosemia. Orthologous to human GALT (galactose-1-phosphate uridylyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 26F6-26F6; 2-21 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (6666264..6668033, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (6666264..6668033, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucose:hexose-1-phosphate uridylyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in UDP-D-galactose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-alpha-D-glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in UDP-galactose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in galactose catabolic process via UDP-galactose	IBA Inferred from Biological aspect of Ancestor more info
involved_in galactose catabolic process via UDP-galactose	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in galactose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in galactose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: Galactose-1-phosphate uridylyltransferase

Names: CG9232-PA; CG9232-PB; Galt-PA; Galt-PB; galactose-1-phosphate uridyltransferase; galactose-1-phosphate uridylyltransferase; galactose-1P uridylyltransferase

NP_001260142.1

EC 2.7.7.12

NP_609062.2

EC 2.7.7.12

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

6666264..6668033 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135218.3 → NP_609062.2 Galactose-1-phosphate uridylyltransferase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609062.2

Status: REVIEWED

UniProtKB/Swiss-Prot

B9EQS8, Q8SXN7, Q9VMA2

UniProtKB/TrEMBL

M9PB52

Related

FBpp0078951

Conserved Domains (2) summary

PRK11720
Location:1 → 350

PRK11720; galactose-1-phosphate uridylyltransferase; Provisional

cd00608
Location:10 → 341

GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...
NM_001273213.1 → NP_001260142.1 Galactose-1-phosphate uridylyltransferase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260142.1

Status: REVIEWED

UniProtKB/Swiss-Prot

B9EQS8, Q8SXN7, Q9VMA2

UniProtKB/TrEMBL

M9PB52

Conserved Domains (2) summary

PRK11720
Location:1 → 350

PRK11720; galactose-1-phosphate uridylyltransferase; Provisional

cd00608
Location:10 → 341

GalT; Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme ...