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    Pot1b protection of telomeres 1B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690237, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Pot1bprovided by RGD
    Official Full Name
    protection of telomeres 1Bprovided by RGD
    Primary source
    RGD:1582873
    See related
    EnsemblRapid:ENSRNOG00000047439 AllianceGenome:RGD:1582873
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G-rich strand telomeric DNA binding activity and telomerase inhibitor activity. Predicted to be involved in regulation of telomere maintenance via telomerase and telomere capping. Predicted to be part of nuclear telomere cap complex. Human ortholog(s) of this gene implicated in colorectal cancer; familial melanoma; hepatocellular carcinoma; lung cancer; and ovarian cancer. Orthologous to human POT1 (protection of telomeres 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Thymus (RPKM 63.9), Spleen (RPKM 44.3) and 9 other tissues See more
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    Genomic context

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    See Pot1b in Genome Data Viewer
    Location:
    9q12
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (9997508..10055752, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (9670355..9728624, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (7845697..7902270, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SIK family kinase 3, pseudogene 1 Neighboring gene vomeronasal 2 receptor, 77 Neighboring gene U6 spliceosomal RNA Neighboring gene Nedd4 binding protein 1, pseudogene 2 Neighboring gene 60S ribosomal protein L7 pseudogene Neighboring gene adhesion G protein-coupled receptor E4 Neighboring gene vomeronasal 2 receptor, pseudogene 138

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-rich strand telomeric DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables telomerase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular senescence IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA recombination at telomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protection from non-homologous end joining at telomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of telomere maintenance via telomerase IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in telomere capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of nuclear telomere cap complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protection of telomeres 1B; protection of telomeres protein 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      9997508..10055752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267869.1 → XP_063123939.1  protection of telomeres protein 1-like isoform X6

      Related
      ENSRNOP00000064381.4, ENSRNOT00000072684.4

    2. XM_039084415.2 → XP_038940343.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    3. XM_006244268.4 → XP_006244330.1  protection of telomeres protein 1-like isoform X4

      See identical proteins and their annotated locations for XP_006244330.1

      UniProtKB/TrEMBL
      M0R4T5
      Related
      ENSRNOP00000070503.3, ENSRNOT00000080575.3
      Conserved Domains (2) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd04498
      Location:161 → 279
      hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

    4. XM_063267870.1 → XP_063123940.1  protection of telomeres protein 1-like isoform X6

    5. XM_063267866.1 → XP_063123936.1  protection of telomeres protein 1-like isoform X4

      UniProtKB/TrEMBL
      M0R4T5
      Related
      ENSRNOP00000101595.1, ENSRNOT00000149606.1

    6. XM_039084421.2 → XP_038940349.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    7. XM_063267871.1 → XP_063123941.1  protection of telomeres protein 1-like isoform X7

    8. XM_039084417.2 → XP_038940345.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    9. XM_039084416.2 → XP_038940344.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    10. XM_063267867.1 → XP_063123937.1  protection of telomeres protein 1-like isoform X4

      UniProtKB/TrEMBL
      M0R4T5

    11. XM_039084419.2 → XP_038940347.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    12. XM_039084422.2 → XP_038940350.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    13. XM_063267865.1 → XP_063123935.1  protection of telomeres protein 1-like isoform X4

      UniProtKB/TrEMBL
      M0R4T5

    14. XM_039084418.1 → XP_038940346.1  protection of telomeres protein 1-like isoform X2

      Conserved Domains (3) summary
      smart00976
      Location:11 → 141
      Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
      cd20374
      Location:345 → 650
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region
      pfam16686
      Location:153 → 299
      POT1PC; ssDNA-binding domain of telomere protection protein

    15. XM_063267868.1 → XP_063123938.1  protection of telomeres protein 1-like isoform X5

    16. XM_063267864.1 → XP_063123934.1  protection of telomeres protein 1-like isoform X3

    17. XM_063267863.1 → XP_063123933.1  protection of telomeres protein 1-like isoform X1

    18. XM_039084426.2 → XP_038940354.1  protection of telomeres protein 1-like isoform X9

      Conserved Domains (1) summary
      cd20374
      Location:18 → 323
      Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

    19. XM_063267872.1 → XP_063123942.1  protection of telomeres protein 1-like isoform X8

    RNA

    1. XR_010054687.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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