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    ZNF737 zinc finger protein 737 [ Homo sapiens (human) ]

    Gene ID: 100129842, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF737provided by HGNC
    Official Full Name
    zinc finger protein 737provided by HGNC
    Primary source
    HGNC:HGNC:32468
    See related
    Ensembl:ENSG00000237440 MIM:603984; AllianceGenome:HGNC:32468
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF102
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in thyroid (RPKM 7.4), ovary (RPKM 4.3) and 23 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF737 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (20530276..20565781, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (20667808..20703634, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (20720798..20748587, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 826, pseudogene Neighboring gene uncharacterized LOC124904663 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:20605449-20606295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14378 Neighboring gene BCL2 interacting protein 3 pseudogene 22 Neighboring gene uncharacterized LOC105372317 Neighboring gene BCL2 interacting protein 3 pseudogene 23 Neighboring gene uncharacterized LOC105372316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14380 Neighboring gene vomeronasal 1 receptor 78 pseudogene Neighboring gene uncharacterized LOC105372318 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:20796649-20796907

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
    2. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    3. The sequence of the human genome. Venter JC, et al. Science, 2001 Feb 16. PMID 11181995
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article
    5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 737
    Names
    zinc finger protein 102 (Y3)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159293.2 → NP_001152765.1  zinc finger protein 737

      See identical proteins and their annotated locations for NP_001152765.1

      Status: VALIDATED

      Source sequence(s)
      AC008554, AI857360, BC015765, DA043454
      Consensus CDS
      CCDS54238.1
      UniProtKB/Swiss-Prot
      C9JHM3, O75373
      Related
      ENSP00000395733.3, ENST00000427401.9
      Conserved Domains (5) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:143 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 43
      KRAB; KRAB box
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      20530276..20565781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006722597.5 → XP_006722660.1  zinc finger protein 737 isoform X2

      See identical proteins and their annotated locations for XP_006722660.1

      Conserved Domains (5) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:143 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 43
      KRAB; KRAB box
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain

    2. XM_005259697.5 → XP_005259754.1  zinc finger protein 737 isoform X1

      See identical proteins and their annotated locations for XP_005259754.1

      Conserved Domains (5) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:143 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 43
      KRAB; KRAB box
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain

    3. XM_047438008.1 → XP_047293964.1  zinc finger protein 737 isoform X5

    4. XM_017026117.3 → XP_016881606.1  zinc finger protein 737 isoform X6

    5. XM_011527598.4 → XP_011525900.1  zinc finger protein 737 isoform X1

      See identical proteins and their annotated locations for XP_011525900.1

      Conserved Domains (5) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:143 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 43
      KRAB; KRAB box
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain

    6. XM_011527599.4 → XP_011525901.1  zinc finger protein 737 isoform X2

      See identical proteins and their annotated locations for XP_011525901.1

      Conserved Domains (5) summary
      smart00349
      Location:4 → 62
      KRAB; krueppel associated box
      COG5048
      Location:143 → 528
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:427 → 447
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:6 → 43
      KRAB; KRAB box
      pfam13465
      Location:383 → 408
      zf-H2C2_2; Zinc-finger double domain

    7. XM_047438007.1 → XP_047293963.1  zinc finger protein 737 isoform X4

    8. XM_047438006.1 → XP_047293962.1  zinc finger protein 737 isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      20667808..20703634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054319452.1 → XP_054175427.1  zinc finger protein 737 isoform X2

    2. XM_054319450.1 → XP_054175425.1  zinc finger protein 737 isoform X1

    3. XM_054319455.1 → XP_054175430.1  zinc finger protein 737 isoform X5

    4. XM_054319456.1 → XP_054175431.1  zinc finger protein 737 isoform X6

    5. XM_054319449.1 → XP_054175424.1  zinc finger protein 737 isoform X1

    6. XM_054319451.1 → XP_054175426.1  zinc finger protein 737 isoform X2

    7. XM_054319454.1 → XP_054175429.1  zinc finger protein 737 isoform X4

    8. XM_054319453.1 → XP_054175428.1  zinc finger protein 737 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O75373.3 GenPept UniProtKB/Swiss-Prot:O75373

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