Elf1 E74 like ETS transcription factor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Elf1provided by MGI
Official Full Name: E74 like ETS transcription factor 1provided by MGI
Primary source: MGI:MGI:107180
See related: Ensembl:ENSMUSG00000036461 AllianceGenome:MGI:107180
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: p70; Sts1; Elf-1; mElf-1
Summary: Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within negative regulation of T cell receptor signaling pathway and regulation of cytokine production. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ELF1 (E74 like ETS transcription factor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 22.3), bladder adult (RPKM 13.4) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 42.67 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (79718619..79819916)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (79481174..79582491)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
Title: ELF1/PRR11/ARP2/3 promoted trophoblast cells proliferation and motility in early pregnancy.
E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
Title: E74-like factor 1 contributes to nerve trauma-induced nociceptive hypersensitivity through transcriptionally activating matrix metalloprotein-9 in dorsal root ganglion neurons.
Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression
Title: Green Tea Polyphenol EGCG Upregulates Tollip Expression by Suppressing Elf-1 Expression.
Herein, the authors demonstrate that mice lacking Sts expression are significantly resistant to infection by the live vaccine strain of Francisella tularensis.
Title: Increased Resistance to Intradermal Francisella tularensis LVS Infection by Inactivation of the Sts Phosphatases.
Whereas the proportion of NK cells in Elf-1(-/-) mice was normal, the proportion of NKT cells was significantly reduced in the thymus and periphery of Elf-1(-/-) mice compared with wild-type mice.
Title: Differential requirements for the Ets transcription factor Elf-1 in the development of NKT cells and NK cells.
crystal structure of the phosphatase domain of Sts-1, Sts-1(PGM), was determined at pH 4.6.The asymmetric unit contains two independent molecules and each active site is occupied by a sulfate ion.
Title: The 1.35 A resolution structure of the phosphatase domain of the suppressor of T-cell receptor signaling protein in complex with sulfate.
The Sts-1,2 proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
Title: The Sts proteins target tyrosine phosphorylated, ubiquitinated proteins within TCR signaling pathways.
These results suggest that several Ets factors, including Fli1 itself, are involved in the transcriptional regulation of Fli1 in lymphocytes.
Title: Ets factors and a newly identified polymorphism regulate Fli1 promoter activity in lymphocytes.
Results suggest that GATA-2, Fli-1 and Elf-1 are key components of an enhanceosome responsible for activating SCL transcription and establishing the transcriptional programme required for HSC formation.
Title: Establishing the transcriptional programme for blood: the SCL stem cell enhancer is regulated by a multiprotein complex containing Ets and GATA factors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Elf1 (e-PCR), detects polymorphism
- UniSTS:547212

U19617 (e-PCR)
- UniSTS:180707

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ETS-related transcription factor Elf-1

Names: E74-like factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286411.2 → NP_001273340.1 ETS-related transcription factor Elf-1 isoform 1

See identical proteins and their annotated locations for NP_001273340.1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

Consensus CDS

CCDS27301.1

UniProtKB/Swiss-Prot

Q60775

UniProtKB/TrEMBL

Q3U1B2, Q3V1H4

Related

ENSMUSP00000106459.2, ENSMUST00000110835.3

Conserved Domains (2) summary

smart00413
Location:207 → 289

ETS; erythroblast transformation specific domain

pfam12310
Location:2 → 111

Elf-1_N; Transcription factor protein N terminal
NM_001286412.2 → NP_001273341.1 ETS-related transcription factor Elf-1 isoform 2

See identical proteins and their annotated locations for NP_001273341.1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

Consensus CDS

CCDS88722.1

UniProtKB/TrEMBL

A0A2I3BPX9, Q3U1B2

Related

ENSMUSP00000153956.2, ENSMUST00000227192.2

Conserved Domains (2) summary

smart00413
Location:170 → 252

ETS; erythroblast transformation specific domain

pfam12310
Location:2 → 69

Elf-1_N; Transcription factor protein N terminal
NM_001422240.1 → NP_001409169.1 ETS-related transcription factor Elf-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

UniProtKB/Swiss-Prot

Q60775

UniProtKB/TrEMBL

Q3U1B2, Q3V1H4
NM_001422241.1 → NP_001409170.1 ETS-related transcription factor Elf-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

UniProtKB/Swiss-Prot

Q60775

UniProtKB/TrEMBL

Q3U1B2, Q3V1H4
NM_001422242.1 → NP_001409171.1 ETS-related transcription factor Elf-1 isoform 1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

UniProtKB/Swiss-Prot

Q60775

UniProtKB/TrEMBL

Q3U1B2, Q3V1H4
NM_001422243.1 → NP_001409172.1 ETS-related transcription factor Elf-1 isoform 2

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

UniProtKB/TrEMBL

A0A2I3BPX9, Q3U1B2
NM_001422244.1 → NP_001409173.1 ETS-related transcription factor Elf-1 isoform 3

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

UniProtKB/TrEMBL

Q3UQ47
NM_007920.5 → NP_031946.1 ETS-related transcription factor Elf-1 isoform 1

See identical proteins and their annotated locations for NP_031946.1

Status: VALIDATED

Source sequence(s)

AC129216, AC151994

Consensus CDS

CCDS27301.1

UniProtKB/Swiss-Prot

Q60775

UniProtKB/TrEMBL

Q3U1B2, Q3V1H4

Related

ENSMUSP00000046515.6, ENSMUST00000040131.13

Conserved Domains (2) summary

smart00413
Location:207 → 289

ETS; erythroblast transformation specific domain

pfam12310
Location:2 → 111

Elf-1_N; Transcription factor protein N terminal