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    SSR3 signal sequence receptor subunit 3 [ Homo sapiens (human) ]

    Gene ID: 6747, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SSR3provided by HGNC
    Official Full Name
    signal sequence receptor subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:11325
    See related
    Ensembl:ENSG00000114850 MIM:606213; AllianceGenome:HGNC:11325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRAPG
    Summary
    The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in thyroid (RPKM 48.0), endometrium (RPKM 38.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SSR3 in Genome Data Viewer
    Location:
    3q25.31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (156539553..156555117, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (159314207..159329772, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (156257342..156272906, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 1 Neighboring gene uncharacterized LOC124906298 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156174295-156175494 Neighboring gene KCNAB1 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:156180752-156181363 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:156200851-156202050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:156251527-156252026 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20729 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14836 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14838 Neighboring gene TIPARP antisense RNA 1 Neighboring gene TCDD inducible poly(ADP-ribose) polymerase Neighboring gene methyltransferase like 15 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Dissecting the molecular organization of the translocon-associated protein complex. Pfeffer S, et al. Nat Commun, 2017 Feb 20. PMID 28218252, Free PMC Article
    2. Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy. Hu Q, et al. Cell Signal, 2023 Nov. PMID 37652395
    3. Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma. Huang S, et al. Hum Pathol, 2018 Nov. PMID 29940286
    4. Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation. Ng BG, et al. J Inherit Metab Dis, 2019 Sep. PMID 30945312, Free PMC Article
    5. TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms. Dittner-Moormann S, et al. J Med Genet, 2021 Mar. PMID 32332102

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.
      Title: Signal sequence receptor subunit 3: A novel indicator of immunosuppressive tumor microenvironment and clinical benefits from immunotherapy.
    2. Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.
      Title: Translocon-associated Protein Subunit SSR3 Determines and Predicts Susceptibility to Paclitaxel in Breast Cancer and Glioblastoma.
    3. The Role of TRAPgamma/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.
      Title: The Role of TRAPγ/SSR3 in Preproinsulin Translocation Into the Endoplasmic Reticulum.
    4. TRAPgamma-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.
      Title: TRAPγ-CDG shows asymmetric glycosylation and an effect on processing of proteins required in higher organisms.
    5. Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.
      Title: Mutations in the translocon-associated protein complex subunit SSR3 cause a novel congenital disorder of glycosylation.
    6. SSR3 acts as an oncogene in hepatocellular carcinoma with overexpression predicting poor survival.
      Title: Overexpression of signal sequence receptor γ predicts poor survival in patients with hepatocellular carcinoma.
    7. Data suggest that the mutation leads to complete absence of TRAP gamma (SSR3).
      Title: Dissecting the molecular organization of the translocon-associated protein complex.
    8. translocon-associated protein subunit gamma (TRAPgamma) was identified as a novel TR3 binding partner.
      Title: The orphan nuclear receptor TR3/Nur77 regulates ER stress and induces apoptosis via interaction with TRAPγ.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides upregulate gene expression of signal sequence receptor, gamma (translocon-associated protein gamma; SSR3) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in SRP-dependent cotranslational protein targeting to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocon-associated protein subunit gamma
    Names
    SSR gamma
    TRAP-complex gamma subunit
    TRAP-gamma
    signal sequence receptor subunit gamma
    signal sequence receptor, gamma (translocon-associated protein gamma)
    translocon-associated protein gamma subunit

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308197.2 → NP_001295126.1  translocon-associated protein subunit gamma isoform 1

      See identical proteins and their annotated locations for NP_001295126.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC092927, AI225105, AK304364, HY035536
      Consensus CDS
      CCDS77846.1
      UniProtKB/TrEMBL
      C9JA28
      Related
      ENSP00000420641.1, ENST00000467789.5
      Conserved Domains (1) summary
      pfam07074
      Location:12 → 196
      TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

    2. NM_001308204.2 → NP_001295133.1  translocon-associated protein subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_001295133.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA283706
      Consensus CDS
      CCDS82865.1
      UniProtKB/TrEMBL
      C9J365
      Related
      ENSP00000417306.1, ENST00000463503.5
      Conserved Domains (1) summary
      pfam07074
      Location:1 → 131
      TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

    3. NM_001308205.2 → NP_001295134.1  translocon-associated protein subunit gamma isoform 3

      See identical proteins and their annotated locations for NP_001295134.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks a 5' exon, contains an alternate 5' terminal exon, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1. Both variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA725890
      Consensus CDS
      CCDS82865.1
      UniProtKB/TrEMBL
      C9J365
      Related
      ENSP00000420087.1, ENST00000496050.1
      Conserved Domains (1) summary
      pfam07074
      Location:1 → 131
      TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

    4. NM_007107.5 → NP_009038.1  translocon-associated protein subunit gamma isoform 2

      See identical proteins and their annotated locations for NP_009038.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AC092927, AF110647, AI225105, BC017203, BJ997360, BM988383, BU532041, CN409041, CX786292, DA750309
      Consensus CDS
      CCDS3176.1
      UniProtKB/Swiss-Prot
      B2R7D0, B4E2P2, D3DNK5, Q549M4, Q9UNL2
      UniProtKB/TrEMBL
      C9JA28
      Related
      ENSP00000265044.2, ENST00000265044.7
      Conserved Domains (1) summary
      pfam07074
      Location:12 → 183
      TRAP-gamma; Translocon-associated protein, gamma subunit (TRAP-gamma)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      156539553..156555117 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      159314207..159329772 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UNL2.1 GenPept UniProtKB/Swiss-Prot:Q9UNL2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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