FFAR1 free fatty acid receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FFAR1provided by HGNC
Official Full Name: free fatty acid receptor 1provided by HGNC
Primary source: HGNC:HGNC:4498
See related: Ensembl:ENSG00000126266 MIM:603820; AllianceGenome:HGNC:4498
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FFA1R; GPR40; GPCR40
Summary: This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Orthologs: mouse all
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Genomic context

Location:: 19q13.12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (35347902..35353864)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (37892634..37898598)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (35838805..35844766)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].
Title: [The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].
Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
Title: Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.
Title: GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.
Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.
Title: Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.
Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
Title: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.
Title: Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.
Metabolic and physiological role of FFAR1 (GPR40), FFAR4 (GPR120), FFAR3 (GPR41) and FFAR2 (GPR43) is REVIEWED.
Title: Free Fatty Acid Receptors in Health and Disease.
GPR40 represents an important regulator of airway barrier integrity and may be a promising therapeutic target for the treatment of airway diseases.
Title: Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
Periodontal expression of GPR40 and CD36 was upregulated in patients with both metabolic syndrome and periodontitis
Title: Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis.
High GRP40 expression is associated with epileptic seizure.
Title: GPR40 modulates epileptic seizure and NMDA receptor function.

Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	TAS Traceable Author Statement more info	PubMed
enables bioactive lipid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bioactive lipid receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IEA Inferred from Electronic Annotation more info
involved_in ion channel modulating, G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in ligand-gated ion channel signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to fatty acid	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: free fatty acid receptor 1

Names: G-protein coupled receptor 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005303.3 → NP_005294.1 free fatty acid receptor 1

See identical proteins and their annotated locations for NP_005294.1

Status: REVIEWED

Source sequence(s)

KF511268, U62631

Consensus CDS

CCDS12458.1

UniProtKB/Swiss-Prot

O14842, Q0VAS2, Q4VBL4

UniProtKB/TrEMBL

Q0IJ71

Related

ENSP00000246553.2, ENST00000246553.4

Conserved Domains (1) summary

cd15169
Location:6 → 289

7tmA_FFAR1; free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors