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    Chmp2a charged multivesicular body protein 2A [ Mus musculus (house mouse) ]

    Gene ID: 68953, updated on 4-Jan-2025

    Summary

    Official Symbol
    Chmp2aprovided by MGI
    Official Full Name
    charged multivesicular body protein 2Aprovided by MGI
    Primary source
    MGI:MGI:1916203
    See related
    Ensembl:ENSMUSG00000033916 AllianceGenome:MGI:1916203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mVps2; 1500016L11Rik
    Summary
    Predicted to enable phosphatidylcholine binding activity and protein domain specific binding activity. Predicted to be involved in several processes, including mitotic nuclear division; regulation of cell cycle process; and vacuolar transport. Located in cytosol. Is expressed in several structures, including branchial arch; facial prominence; ganglia; gut; and limb bud. Orthologous to human CHMP2A (charged multivesicular body protein 2A). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in placenta adult (RPKM 67.0), bladder adult (RPKM 65.4) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Chmp2a in Genome Data Viewer
    Location:
    7 A1; 7 7.73 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (12765933..12768704, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (13032006..13034777, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 45 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13594963-13595072 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:13595132-13595322 Neighboring gene STARR-positive B cell enhancer ABC_E6511 Neighboring gene CRISPRi-validated cis-regulatory element for Slc27a5, Trim28, Ube2m, Zbtb45, Zfp324 and Zfp446 Neighboring gene STARR-positive B cell enhancer ABC_E6512 Neighboring gene predicted gene, 31649 Neighboring gene tripartite motif-containing 28 Neighboring gene STARR-positive B cell enhancer mm9_chr7:13619992-13620293 Neighboring gene STARR-positive B cell enhancer ABC_E6513 Neighboring gene ubiquitin-conjugating enzyme E2M Neighboring gene myeloid zinc finger 1 Neighboring gene STARR-positive B cell enhancer ABC_E2223

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylcholine binding  
    enables phosphatidylcholine binding  
    enables protein binding PubMed 
    enables protein domain specific binding  
    enables protein domain specific binding  
    Items 1 - 25 of 38
    Process Evidence Code Pubs
    involved_in autophagosome maturation  
    involved_in autophagy  
    involved_in endosome transport via multivesicular body sorting pathway  
    involved_in establishment of protein localization  
    involved_in exit from mitosis  
    involved_in exit from mitosis  
    involved_in late endosome to lysosome transport  
    involved_in late endosome to vacuole transport  
    involved_in membrane fission PubMed 
    involved_in membrane invagination  
    involved_in membrane invagination  
    involved_in midbody abscission  
    involved_in mitotic metaphase chromosome alignment  
    involved_in multivesicular body assembly PubMed 
    involved_in multivesicular body sorting pathway  
    involved_in multivesicular body-lysosome fusion PubMed 
    involved_in negative regulation of centriole elongation  
    involved_in negative regulation of centriole elongation  
    involved_in nuclear membrane reassembly  
    involved_in nuclear membrane reassembly  
    involved_in nucleus organization  
    involved_in plasma membrane repair  
    involved_in positive regulation of exosomal secretion  
    involved_in positive regulation of exosomal secretion  
    involved_in protein homooligomerization  
    involved_in protein homooligomerization  
    involved_in protein polymerization  
    involved_in protein polymerization  
    involved_in protein transport  
    involved_in protein transport  
    involved_in regulation of centrosome duplication  
    involved_in regulation of centrosome duplication  
    involved_in regulation of mitotic spindle assembly  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in vesicle fusion with vacuole PubMed 
    involved_in viral budding from plasma membrane  
    involved_in viral budding via host ESCRT complex  
    involved_in viral release from host cell  
    Items 1 - 25 of 38
    Component Evidence Code Pubs
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    located_in amphisome membrane  
    located_in autophagosome membrane  
    located_in chromatin  
    located_in chromatin  
    located_in cytosol PubMed 
    located_in kinetochore  
    located_in kinetochore microtubule  
    located_in lysosomal membrane  
    part_of membrane coat  
    part_of membrane coat  
    located_in midbody  
    is_active_in multivesicular body  
    located_in multivesicular body membrane  
    located_in nuclear envelope  
    located_in nuclear envelope  
    part_of nuclear pore  
    located_in plasma membrane  

    General protein information

    Preferred Names
    charged multivesicular body protein 2a
    Names
    chromatin modifying protein 2A
    chromatin-modifying protein 2a
    vacuolar protein sorting-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360730.1NP_001347659.1  charged multivesicular body protein 2a isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS20824.1
      UniProtKB/Swiss-Prot
      Q9DB34
      Related
      ENSMUSP00000148218.2, ENSMUST00000210587.2
      Conserved Domains (1) summary
      pfam03357
      Location:17185
      Snf7
    2. NM_001360731.1NP_001347660.1  charged multivesicular body protein 2a isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice junction compared to variant 1, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC121301
      Conserved Domains (1) summary
      pfam03357
      Location:17164
      Snf7
    3. NM_001360733.1NP_001347662.1  charged multivesicular body protein 2a isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC121301
      Consensus CDS
      CCDS90160.1
      UniProtKB/TrEMBL
      A0A1B0GR63, A0A1B0GT75
      Related
      ENSMUSP00000147393.2, ENSMUST00000211626.2
      Conserved Domains (1) summary
      cl21588
      Location:17135
      Snf7
    4. NM_026885.3NP_081161.1  charged multivesicular body protein 2a isoform a

      See identical proteins and their annotated locations for NP_081161.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same isoform (a).
      Source sequence(s)
      AC121301, AK005267, BY157363
      Consensus CDS
      CCDS20824.1
      UniProtKB/Swiss-Prot
      Q9DB34
      Related
      ENSMUSP00000005711.5, ENSMUST00000005711.6
      Conserved Domains (1) summary
      pfam03357
      Location:17185
      Snf7

    RNA

    1. NR_153796.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' end and lacks two alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD)
      Source sequence(s)
      AC121301
      Related
      ENSMUST00000211369.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      12765933..12768704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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