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    Tmc Transmembrane channel-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 26067066, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Tmcprovided by FlyBase
    Official Full Name
    Transmembrane channel-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0267796
    Locus tag
    Dmel_CG46121
    See related
    AllianceGenome:FB:FBgn0267796
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14177; CG3280; CG46121; Dmel\CG46121; DmTMC; dTmc; Tic; tmc; TMC; Tmc-L
    Old locus tag
    Dmel_CG14177; Dmel_CG3280
    Summary
    Predicted to enable mechanosensitive monoatomic ion channel activity. Involved in several processes, including detection of stimulus involved in sensory perception; perception of rate of movement; and positive regulation of mechanosensory behavior. Located in dendrite. Is expressed in several structures, including adult dorsal metathoracic nerve; adult sense organ; antennal lobe projection neuron vPN; coxa-trochanter joint; and sensory neurons. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 36; autosomal recessive nonsyndromic deafness 7; and sensorineural hearing loss. Orthologous to several human genes including TMC3 (transmembrane channel like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tmc in Genome Data Viewer
    Location:
    67C2-67C2; 3-31 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9597764..9614001)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ionotropic receptor 67a Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46246 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Laminin B2 Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 67b

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NT_037436.4 Chromosome 3L Reference Release 6 plus ISO1 MT Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Guo Y, et al. Proc Natl Acad Sci U S A, 2016 Jun 28. PMID 27298354, Free PMC Article
    2. Drosophila proboscis extension response and GCaMP imaging for assaying food appeal based on grittiness. Li Q, et al. STAR Protoc, 2022 Dec 16. PMID 36386873, Free PMC Article
    3. Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc. He L, et al. Curr Biol, 2019 Mar 18. PMID 30853433, Free PMC Article
    4. Mechanosensing in the Drosophila nervous system. Karkali K, et al. Semin Cell Dev Biol, 2017 Nov. PMID 28645543
    5. Distinct functions of TMC channels: a comparative overview. Yue X, et al. Cell Mol Life Sci, 2019 Nov. PMID 31584127, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. As the strength of the responses of wild-type animals was correlated with dendrite curvature, the authors propose that Tmc channels may be activated by membrane curvature in dendrites that are exposed to strain. These findings begin to explain how distinct cellular systems rely on a common molecular pathway for mechanosensory responses.
      Title: Direction Selectivity in Drosophila Proprioceptors Requires the Mechanosensory Channel Tmc.
    2. Drosophila melanogaster transmembrane channel-like (tmc) gene is expressed in the larval class I and class II dendritic arborization (da) neurons and bipolar dendrite (bd) neurons, both of which are known to provide sensory feedback for larval locomotion
      Title: Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion.
    3. the single Drosophila transmembrane channel- like (TMC) protein is expressed in md-L neurons, where it is required for sensing two key textural features of food-hardness and viscosity.
      Title: The Basis of Food Texture Sensation in Drosophila.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mechanosensitive monoatomic ion channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chemosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of sweet taste IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of mechanical stimulus involved in sensory perception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in larval locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in perception of rate of movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proprioception IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of egg-laying behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mechanosensory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in dendrite IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane channel-like
    Names
    CG46121-PC
    CG46121-PD
    Tmc-PC
    Tmc-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9597764..9614001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001316433.1 → NP_001303362.1  transmembrane channel-like, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A0A0U1QT59, M9NDN5
      Conserved Domains (1) summary
      pfam07810
      Location:1237 → 1352
      TMC; TMC domain

    2. NM_001259769.3 → NP_001246698.1  transmembrane channel-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9NDN5
      Conserved Domains (1) summary
      pfam07810
      Location:1138 → 1244
      TMC; TMC domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0U1QT59.1 A0A0U1QT59

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases