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    Clamp Chromatin-linked adaptor for MSL proteins [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35445, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clampprovided by FlyBase
    Official Full Name
    Chromatin-linked adaptor for MSL proteinsprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032979
    Locus tag
    Dmel_CG1832
    See related
    AllianceGenome:FB:FBgn0032979
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1832; clamp; CLAMP; Dmel\CG1832
    Summary
    Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin-protein adaptor activity. Involved in dosage compensation by hyperactivation of X chromosome; maternal-to-zygotic transition of gene expression; and positive regulation of transcription by RNA polymerase II. Located in chromatin and nucleus. Is active in histone locus body. Is expressed in organism. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Clamp in Genome Data Viewer
    Location:
    40F2-40F2; 2-54 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (22165720..22169143, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (22165720..22169143, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43241 Neighboring gene uncharacterized protein Neighboring gene disrupted underground network Neighboring gene long non-coding RNA:CR44809 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome. Jordan W 3rd, et al. Epigenetics Chromatin, 2021 Jun 29. PMID 34187599, Free PMC Article
    2. Sequence reliance of the Drosophila context-dependent transcription factor CLAMP. Hodkinson LJ, et al. Genetics, 2024 Jul 8. PMID 38775472,
    3. CLAMP regulates zygotic genome activation in Drosophila embryos. Colonnetta MM, et al. Genetics, 2021 Oct 2. PMID 34849887, Free PMC Article
    4. Targeting of the Dosage-Compensated Male X-Chromosome during Early Drosophila Development. Rieder LE, et al. Cell Rep, 2019 Dec 24. PMID 31875538, Free PMC Article
    5. Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites. Eggers N, et al. Nucleic Acids Res, 2023 Sep 22. PMID 37602401, Free PMC Article

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequence reliance of the Drosophila context-dependent transcription factor CLAMP.
      Title: Sequence reliance of the Drosophila context-dependent transcription factor CLAMP.
    2. Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
      Title: Interaction of MLE with CLAMP zinc finger is involved in proper MSL proteins binding to chromosomes in Drosophila.
    3. Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
      Title: Physical interaction between MSL2 and CLAMP assures direct cooperativity and prevents competition at composite binding sites.
    4. Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
      Title: Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
    5. Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein.
      Title: Dimerization Activity of a Disordered N-Terminal Domain from Drosophila CLAMP Protein.
    6. CLAMP regulates zygotic genome activation in Drosophila embryos.
      Title: CLAMP regulates zygotic genome activation in Drosophila embryos.
    7. The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.
      Title: The zinc finger protein CLAMP promotes long-range chromatin interactions that mediate dosage compensation of the Drosophila male X-chromosome.
    8. CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
      Title: CLAMP and Zelda function together to promote Drosophila zygotic genome activation.
    9. proper MSL2 positioning requires an interaction with either CLAMP or DNA to initiate dosage compensation in Drosophila males.
      Title: The simultaneous interaction of MSL2 with CLAMP and DNA provides redundancy in the initiation of dosage compensation in Drosophila males.
    10. hese are explained by physical interaction between MSL2 and CLAMP. In vivo, both factors cooperate to compete with nucleosome formation at HAS. The male-specific MSL2 thus synergises with a ubiquitous GA-repeat binding protein for refined X/autosome discrimination
      Title: Factor cooperation for chromosome discrimination in Drosophila.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables chromatin-protein adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dosage compensation by hyperactivation of X chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in maternal-to-zygotic transition of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in histone locus body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Chromatin-linked adaptor for MSL proteins
    Names
    CG1832-PA
    CG1832-PB
    Clamp-PA
    Clamp-PB
    chromatin-linked adaptor for MSL proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      22165720..22169143 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014498.3 → NP_001014498.1  Chromatin-linked adaptor for MSL proteins, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014498.1

      Status: REVIEWED

      Conserved Domains (3) summary
      COG5048
      Location:359 → 498
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:423 → 443
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:464 → 488
      zf-H2C2_2; Zinc-finger double domain

    2. NM_136293.4 → NP_610137.1  Chromatin-linked adaptor for MSL proteins, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610137.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IGP5, Q961A1, Q9V9N4
      Related
      FBpp0085317
      Conserved Domains (3) summary
      COG5048
      Location:344 → 493
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:418 → 438
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:459 → 483
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IGP5 Q8IGP5
    Q961A1 Q961A1
    Q9V9N4 Q9V9N4
    Q9V9N4.1

    Gene LinkOut

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