Commd3 COMM domain containing 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Commd3provided by RGD
Official Full Name: COMM domain containing 3provided by RGD
Primary source: RGD:735116
See related: EnsemblRapid:ENSRNOG00000016383 AllianceGenome:RGD:735116
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in sodium ion transport. Predicted to be located in cytoplasm and nucleus. Orthologous to human COMMD3 (COMM domain containing 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 438.6), Heart (RPKM 405.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (86235863..86239610)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (81327444..81331191)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (85356042..85359835)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Suggest that COMMD3 and COMMD9 may be endogenous regulators of ENaC to regulate Na+ transport through altering ENaC cell surface expression.
Title: Functional interaction of COMMD3 and COMMD9 with the epithelial sodium channel.

Submit: New GeneRIF Correction

General gene information

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Markers

D17Rat154 (e-PCR), detects polymorphism
- UniSTS:226854

RH144129 (e-PCR)
- UniSTS:233375

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: COMM domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198732.3 → NP_942027.1 COMM domain-containing protein 3

See identical proteins and their annotated locations for NP_942027.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000017

UniProtKB/Swiss-Prot

Q6P9U3

Related

ENSRNOP00000022201.5, ENSRNOT00000022201.7

Conserved Domains (1) summary

cd04751
Location:98 → 194

Commd3; COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several ...