Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tab2provided by RGD
Official Full Name: TGF-beta activated kinase 1/MAP3K7 binding protein 2provided by RGD
Primary source: RGD:1309527
See related: EnsemblRapid:ENSRNOG00000016054 AllianceGenome:RGD:1309527
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Map3k7ip2
Summary: Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity; molecular adaptor activity; and zinc ion binding activity. Predicted to be involved in several processes, including non-canonical NF-kappaB signal transduction; positive regulation of canonical NF-kappaB signal transduction; and response to bacterium. Predicted to be located in cytosol; endosome membrane; and lysosomal membrane. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in cardiomyopathy; congenital heart disease; and ovary epithelial cancer. Orthologous to human TAB2 (TGF-beta activated kinase 1 (MAP3K7) binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 106.9), Thymus (RPKM 102.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (4195400..4245485, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (2375026..2425115, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (1999574..2017574, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.
Title: MiR-199a target regulates TAB2 to promote the migration of endodermal progenitor cells and inhibit deep vein thrombosis in rats.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139417 (e-PCR)
- UniSTS:221503

RH131330 (e-PCR)
- UniSTS:214613

STS-T59224 (e-PCR)
- UniSTS:25226

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in defense response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in heart development	IBA Inferred from Biological aspect of Ancestor more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in non-canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Names: TGF-beta-activated kinase 1-binding protein 2; mitogen-activated protein kinase kinase kinase 7-interacting protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001393814.1 → NP_001380743.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q5U303

UniProtKB/TrEMBL

A6JP22

Related

ENSRNOP00000021904.3, ENSRNOT00000021905.8

Conserved Domains (4) summary

smart00547
Location:667 → 690

ZnF_RBZ; Zinc finger domain

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins

sd00029
Location:668 → 687

zf-RanBP2; RanBP2-type Zn finger [structural motif]

pfam10473
Location:541 → 619

CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

4195400..4245485 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063288633.1 → XP_063144703.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X2

UniProtKB/Swiss-Prot

Q5U303

UniProtKB/TrEMBL

A6JP22
XM_039110915.2 → XP_038966843.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_039110917.2 → XP_038966845.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_039110921.2 → XP_038966849.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_039110919.2 → XP_038966847.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Conserved Domains (1) summary

cd14362
Location:9 → 50

CUE_TAB2_TAB3; CUE domain found in the N-terminal of TGF-beta-activated kinase 1 and MAP3K7-binding proteins TAB2, TAB3 and similar proteins
XM_063288630.1 → XP_063144700.1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001012062.1: Suppressed sequence

Description

NM_001012062.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.