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    Stam signal transducing adaptor molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 498798, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stamprovided by RGD
    Official Full Name
    signal transducing adaptor moleculeprovided by RGD
    Primary source
    RGD:1564499
    See related
    EnsemblRapid:ENSRNOG00000060817 AllianceGenome:RGD:1564499
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1564499
    Summary
    Predicted to enable ubiquitin-like protein ligase binding activity. Predicted to be involved in positive regulation of exosomal secretion; protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway; and regulation of extracellular exosome assembly. Predicted to be located in cytosol and intracellular membrane-bounded organelle. Predicted to be part of ESCRT-0 complex. Orthologous to human STAM (signal transducing adaptor molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 159.5), Kidney (RPKM 156.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stam in Genome Data Viewer
    Location:
    17q12.3
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (82028779..82074717)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (77120235..77166173)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (81209795..81256111)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 Neighboring gene 3-hydroxyacyl-CoA dehydratase 1 Neighboring gene transmembrane protein 236 Neighboring gene uncharacterized LOC134482611 Neighboring gene mannose receptor, C type 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interaction of the deafness-dystonia protein DDP/TIMM8a with the signal transduction adaptor molecule STAM1. Blackstone C, et al. Biochem Biophys Res Commun, 2003 May 30. PMID 12745081
    2. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. Colombo M, et al. J Cell Sci, 2013 Dec 15. PMID 24105262
    3. The ubiquitin ligase deltex-3l regulates endosomal sorting of the G protein-coupled receptor CXCR4. Holleman J, et al. Mol Biol Cell, 2014 Jun 15. PMID 24790097, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of exosomal secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of extracellular exosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of ESCRT-0 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ESCRT-0 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    signal transducing adapter molecule 1
    Names
    signal transducing adaptor molecule (SH3 domain and ITAM motif) 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109121.2 → NP_001102591.1  signal transducing adapter molecule 1

      See identical proteins and their annotated locations for NP_001102591.1

      Status: PROVISIONAL

      Source sequence(s)
      BC168933
      UniProtKB/TrEMBL
      A0A0G2JTT5, A0A0G2K9W6, B5DF55
      Related
      ENSRNOP00000075157.1, ENSRNOT00000077368.3
      Conserved Domains (3) summary
      cd11964
      Location:213 → 267
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd03568
      Location:9 → 142
      VHS_STAM; VHS domain family, STAM subfamily; members include STAM (Signal Transducing Adaptor Molecule), EAST (EGFR-associated protein with SH3 and TAM domains) and Hbp (Hrs-binding protein). Collectively, they are referred to as STAM. All STAMs have at their ...
      pfam03127
      Location:308 → 379
      GAT; GAT domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      82028779..82074717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600651.3 → XP_017456140.2  signal transducing adapter molecule 1 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTT5, A0A8I6A2K6
      Related
      ENSRNOP00000085119.1, ENSRNOT00000119151.2
      Conserved Domains (3) summary
      cd11964
      Location:211 → 265
      SH3_STAM1; Src homology 3 domain of Signal Transducing Adaptor Molecule 1
      cd17000
      Location:11 → 137
      VHS_STAM1; VHS (Vps27/Hrs/STAM) domain of Signal Transducing Adapter Molecule 1
      cd21389
      Location:301 → 377
      GAT_STAM1; non-canonical GAT domain found in signal transducing adapter molecule 1 (STAM-1) and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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