Capza2 capping actin protein of muscle Z-line subunit alpha 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Capza2provided by RGD
Official Full Name: capping actin protein of muscle Z-line subunit alpha 2provided by RGD
Primary source: RGD:1549770
See related: EnsemblRapid:ENSRNOG00000056207 AllianceGenome:RGD:1549770
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Predicted to be located in brush border and membrane. Predicted to be part of F-actin capping protein complex. Predicted to be active in cortical cytoskeleton. Orthologous to human CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 1273.4), Heart (RPKM 779.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (46944040..46979930)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (45978142..46014032)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (44936290..44972270)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

BF407498 (e-PCR)
- UniSTS:248601

ECD20142 (e-PCR)
- UniSTS:301146

AA924038 (e-PCR)
- UniSTS:261478

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of F-actin capping protein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of F-actin capping protein complex	IEA Inferred from Electronic Annotation more info
part_of F-actin capping protein complex	ISO Inferred from Sequence Orthology more info
located_in brush border	ISO Inferred from Sequence Orthology more info
is_active_in cortical cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cortical cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: F-actin-capping protein subunit alpha-2

Names: capZ alpha-2; capping actin protein of muscle Z-line alpha subunit 2; capping protein (actin filament) muscle Z-line, alpha 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.