Tppp tubulin polymerization promoting protein [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpppprovided by RGD
Official Full Name: tubulin polymerization promoting proteinprovided by RGD
Primary source: RGD:1310121
See related: EnsemblRapid:ENSRNOG00000028261 AllianceGenome:RGD:1310121
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: TPPP/p25; RGD1310121
Summary: Predicted to enable several functions, including magnesium ion binding activity; microtubule nucleator activity; and protein homodimerization activity. Involved in myelin assembly and positive regulation of myelination. Located in postsynaptic Golgi apparatus. Orthologous to human TPPP (tubulin polymerization promoting protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 426.2), Heart (RPKM 161.1) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (31085680..31109703, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (29257111..29281134, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (31866755..31890778, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results demonstrate that TPPP on Golgi outposts are important for local microtubule nucleation and myelin sheath elongation.
Title: The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination.
Exophagy, with or without expression of TPPP, may be an important physiological mechanism for unconventional secretion of alpha-synuclein from dopaminergic neurons.
Title: Tubulin polymerization-promoting protein (TPPP/p25α) promotes unconventional secretion of α-synuclein through exophagy by impairing autophagosome-lysosome fusion.
Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
Title: Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein.
These results support an essential role for TPPP/p25 in oligodendrocyte differentiation likely via rearrangement of the microtubule system during the process elongation prior to the onset of myelination.
Title: Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation.
Malfunction of the proteasomal system, leading to the accumulation of aggregation prone proteins and the pro-aggregatory protein TPPP/p25alpha, is causally related to the protein aggregation process in a variety of neurodegenerative diseases.
Title: The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables membrane scission GTPase motor activity	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables microtubule nucleator activity	IEA Inferred from Electronic Annotation more info
enables microtubule nucleator activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	IEA Inferred from Electronic Annotation more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in astral microtubule organization	IEA Inferred from Electronic Annotation more info
involved_in astral microtubule organization	ISO Inferred from Sequence Orthology more info
involved_in astral microtubule organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule bundle formation	IEA Inferred from Electronic Annotation more info
involved_in microtubule bundle formation	ISO Inferred from Sequence Orthology more info
involved_in microtubule bundle formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule nucleation by microtubule organizing center	IEA Inferred from Electronic Annotation more info
involved_in microtubule nucleation by microtubule organizing center	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation by microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule polymerization	IEA Inferred from Electronic Annotation more info
involved_in microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in myelin assembly	IEA Inferred from Electronic Annotation more info
involved_in myelin assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myelin assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tubulin deacetylation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tubulin deacetylation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myelination	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myelination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of myelination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein polymerization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein-containing complex assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
is_active_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
colocalizes_with microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
located_in microtubule bundle	IEA Inferred from Electronic Annotation more info
located_in microtubule bundle	ISO Inferred from Sequence Orthology more info
located_in microtubule organizing center	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tubulin polymerization-promoting protein

Names: 25 kDa brain-specific protein; p25-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.