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    Tent4b terminal nucleotidyltransferase 4B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 307745, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tent4bprovided by RGD
    Official Full Name
    terminal nucleotidyltransferase 4Bprovided by RGD
    Primary source
    RGD:1309587
    See related
    EnsemblRapid:ENSRNOG00000024212 AllianceGenome:RGD:1309587
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Papd5
    Summary
    Predicted to enable guanylyltransferase activity; poly(A) RNA polymerase activity; and telomerase RNA binding activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of telomere maintenance via telomerase; and regulation of mRNA stability. Predicted to be located in cytosol and plasma membrane. Predicted to be part of TRAMP complex. Predicted to be active in nucleolus. Orthologous to human TENT4B (terminal nucleotidyltransferase 4B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 113.0), Heart (RPKM 112.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tent4b in Genome Data Viewer
    Location:
    19p11
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (34984244..35042423, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (18807616..18868969, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (19771289..19834759, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098503 Neighboring gene bromodomain containing 7 Neighboring gene adenylate cyclase 7 Neighboring gene uncharacterized LOC134483299 Neighboring gene HEAT repeat containing 3 Neighboring gene uncharacterized LOC134483300 Neighboring gene uncharacterized LOC108348906 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mixed tailing by TENT4A and TENT4B shields mRNA from rapid deadenylation. Lim J, et al. Science, 2018 Aug 17. PMID 30026317
    2. Essential role for non-canonical poly(A) polymerase GLD4 in cytoplasmic polyadenylation and carbohydrate metabolism. Shin J, et al. Nucleic Acids Res, 2017 Jun 20. PMID 28383716, Free PMC Article
    3. Maturation of mammalian H/ACA box snoRNAs: PAPD5-dependent adenylation and PARN-dependent trimming. Berndt H, et al. RNA, 2012 May. PMID 22442037, Free PMC Article
    4. Interaction profiling identifies the human nuclear exosome targeting complex. Lubas M, et al. Mol Cell, 2011 Aug 19. PMID 21855801
    5. PAPD5-mediated 3' adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease. Boele J, et al. Proc Natl Acad Sci U S A, 2014 Aug 5. PMID 25049417, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanylyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly(A) RNA polymerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) RNA polymerase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables telomerase RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in RNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histone mRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in miRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of nuclear-transcribed mRNA poly(A) tail shortening ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in polyadenylation-dependent ncRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of 3'-UTR-mediated mRNA stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TRAMP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TRAMP complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    terminal nucleotidyltransferase 4B
    Names
    PAP associated domain containing 5
    PAP-associated domain-containing protein 5
    non-canonical poly(A) RNA polymerase PAPD5
    poly(A) RNA polymerase D5, non-canonical
    NP_001100886.2
    NP_001388155.1
    NP_001401942.1
    NP_001401944.1
    XP_038953651.1
    XP_038953652.1
    XP_063134086.1
    XP_063134087.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107416.2 → NP_001100886.2  terminal nucleotidyltransferase 4B isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GKZ7
      Related
      ENSRNOP00000062854.2, ENSRNOT00000067582.4

    2. NM_001401226.1 → NP_001388155.1  terminal nucleotidyltransferase 4B isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GKZ7
      Related
      ENSRNOP00000083622.2, ENSRNOT00000108347.2

    3. NM_001415013.2 → NP_001401942.1  terminal nucleotidyltransferase 4B isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GKZ7
      Related
      ENSRNOP00000111022.1, ENSRNOT00000128688.1

    4. NM_001415015.2 → NP_001401944.1  terminal nucleotidyltransferase 4B isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/TrEMBL
      A0A8I6GKZ7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      34984244..35042423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097724.2 → XP_038953652.1  terminal nucleotidyltransferase 4B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K239, A0A8I6G9A0
      Conserved Domains (1) summary
      COG5260
      Location:134 → 455
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. XM_039097723.2 → XP_038953651.1  terminal nucleotidyltransferase 4B isoform X1

      UniProtKB/TrEMBL
      A0A0G2K239, A0A8I6G9A0
      Conserved Domains (1) summary
      COG5260
      Location:134 → 455
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    3. XM_063278016.1 → XP_063134086.1  terminal nucleotidyltransferase 4B isoform X2

      UniProtKB/TrEMBL
      A6KDA3, D3ZBG8

    4. XM_063278017.1 → XP_063134087.1  terminal nucleotidyltransferase 4B isoform X3

      UniProtKB/TrEMBL
      A6KDA3, D3ZBG8
    Nucleotide Protein Strain
    Heading Accession and Version

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