Nudt5 nudix hydrolase 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nudt5provided by RGD
Official Full Name: nudix hydrolase 5provided by RGD
Primary source: RGD:1359284
See related: EnsemblRapid:ENSRNOG00000017741 AllianceGenome:RGD:1359284
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including magnesium ion binding activity; protein homodimerization activity; and pyrophosphatase activity. Predicted to be involved in D-ribose catabolic process; chromatin remodeling; and nucleoside phosphate metabolic process. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in nucleus. Orthologous to human NUDT5 (nudix hydrolase 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 146.6), Kidney (RPKM 123.4) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17q12.3

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (77345041..77368308, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (72435690..72459008, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (76387027..76410309, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISO Inferred from Sequence Orthology more info
NOT enables 5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables 8-oxo-GDP phosphatase activity	IEA Inferred from Electronic Annotation more info
enables 8-oxo-dGDP phosphatase activity	ISO Inferred from Sequence Orthology more info
enables 8-oxo-dGDP phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ADP-ribose diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ADP-ribose diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables ADP-ribose diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables ADP-sugar diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables ADP-sugar diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrophosphatase activity	IEA Inferred from Electronic Annotation more info
enables snoRNA binding	ISO Inferred from Sequence Orthology more info
enables snoRNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ATP generation from poly-ADP-D-ribose	ISO Inferred from Sequence Orthology more info
involved_in D-ribose catabolic process	ISO Inferred from Sequence Orthology more info
involved_in D-ribose catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within nucleobase-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribonucleoside diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ribonucleoside diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribose phosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ADP-sugar pyrophosphatase

Names: 8-oxo-dGDP phosphatase; nuclear ATP-synthesis protein NUDIX5; nucleoside diphosphate-linked moiety X motif 5; nudix (nucleoside diphosphate linked moiety X)-type motif 5; nudix motif 5; nudix-type motif 5

NP_001007734.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

XP_008770097.1

EC 2.7.7.96

EC 3.6.1.13

EC 3.6.1.58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007733.1 → NP_001007734.1 ADP-sugar pyrophosphatase

See identical proteins and their annotated locations for NP_001007734.1

Status: PROVISIONAL

Source sequence(s)

BC079176

UniProtKB/Swiss-Prot

Q6AY63

UniProtKB/TrEMBL

A0A140TAD1

Related

ENSRNOP00000075734.1, ENSRNOT00000082669.3

Conserved Domains (1) summary

cd03424
Location:60 → 207

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

77345041..77368308 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008771875.4 → XP_008770097.1 ADP-sugar pyrophosphatase isoform X1

UniProtKB/TrEMBL

A0A140TAD1

Conserved Domains (1) summary

cd03424
Location:60 → 204

ADPRase_NUDT5; ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+, ...