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    Fkbp4 FKBP prolyl isomerase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 260321, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fkbp4provided by RGD
    Official Full Name
    FKBP prolyl isomerase 4provided by RGD
    Primary source
    RGD:628729
    See related
    EnsemblRapid:ENSRNOG00000006444 AllianceGenome:RGD:628729
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    p59; FKBP-4; FKBP-52
    Summary
    Enables copper-dependent protein binding activity and tau protein binding activity. Involved in copper ion transport and negative regulation of microtubule polymerization. Located in several cellular components, including axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 622.0), Liver (RPKM 546.3) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Fkbp4 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (163389464..163397918, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (161703379..161711833, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (161748993..161757447, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene nuclear receptor interacting protein 2 Neighboring gene integrin alpha FG-GAP repeat containing 2 Neighboring gene uncharacterized LOC120102402 Neighboring gene uncharacterized LOC102554670 Neighboring gene pregnancy-zone protein

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables GTP binding  
    enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity  
    enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity  
    enables copper-dependent protein binding PubMed 
    enables heat shock protein binding  
    enables nuclear glucocorticoid receptor binding  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables peptidyl-prolyl cis-trans isomerase activity  
    enables phosphoprotein binding  
    enables tau protein binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within androgen receptor signaling pathway  
    involved_in chaperone-mediated protein folding  
    involved_in chaperone-mediated protein folding  
    involved_in chaperone-mediated protein folding  
    involved_in copper ion transport PubMed 
    acts_upstream_of_or_within embryo implantation  
    acts_upstream_of_or_within male sex differentiation  
    involved_in negative regulation of microtubule polymerization PubMed 
    involved_in negative regulation of microtubule polymerization or depolymerization  
    involved_in negative regulation of neuron projection development  
    acts_upstream_of_or_within prostate gland development  
    acts_upstream_of_or_within protein-containing complex localization  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within reproductive structure development  
    acts_upstream_of_or_within steroid hormone receptor complex assembly  
    Component Evidence Code Pubs
    located_in axonal growth cone PubMed 
    is_active_in cytoplasm  
    located_in cytosol PubMed 
    located_in cytosol  
    located_in cytosol  
    located_in microtubule  
    located_in mitochondrion  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus  
    located_in nucleus  
    located_in perinuclear region of cytoplasm PubMed 
    part_of protein-containing complex PubMed 

    General protein information

    Preferred Names
    peptidyl-prolyl cis-trans isomerase FKBP4
    Names
    52 kDa FK506-binding protein
    52 kDa FKBP
    59 kDa immunophilin
    FK506 binding protein 52
    FK506-binding protein 4
    FKBP52 protein
    FKBP59
    HBI
    HSP-binding immunophilin
    PPIase FKBP4
    immunophilin FKBP52
    rotamase
    NP_001178792.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191863.1NP_001178792.1  peptidyl-prolyl cis-trans isomerase FKBP4

      See identical proteins and their annotated locations for NP_001178792.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      A6IM14, Q8K3U8, Q9QVC8
      UniProtKB/TrEMBL
      A0A8I5ZLF1
      Related
      ENSRNOP00000008737.6, ENSRNOT00000008737.8
      Conserved Domains (5) summary
      sd00006
      Location:274301
      TPR; TPR repeat [structural motif]
      pfam00254
      Location:43134
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
      pfam00515
      Location:321352
      TPR_1; Tetratricopeptide repeat
      pfam07719
      Location:354386
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:322384
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      163389464..163397918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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