Sh2b1 SH2B adaptor protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sh2b1provided by RGD
Official Full Name: SH2B adaptor protein 1provided by RGD
Primary source: RGD:620132
See related: EnsemblRapid:ENSRNOG00000049181 AllianceGenome:RGD:620132
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sh2b; Sh2-b; Sh2bpsm1
Summary: Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Predicted to be involved in intracellular signal transduction; positive regulation of mitotic nuclear division; and regulation of DNA biosynthetic process. Predicted to act upstream of or within cell motility; lamellipodium assembly; and positive regulation of SMAD protein signal transduction. Predicted to be located in cytoplasm and nucleus. Predicted to be active in plasma membrane. Orthologous to human SH2B1 (SH2B adaptor protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 65.5), Kidney (RPKM 60.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (190479211..190492030, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (181048622..181057036, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (197878839..197888223, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-14 2-3 p not only mitigate cardiac hypertrophy by directly inhibit the expression of gene SH2B1, but also can protect mitochondrial function in cardiac hypertrophy of vitro and vivo.
Title: Overexpression of miR-142-3p improves mitochondrial function in cardiac hypertrophy.
SH2B1 overexpression resulted in increased viability, reduced lactate dehydrogenase release and a reduction in the expression levels of proteins associated with the apoptotic cascade in PC12 cells under the oxygenglucose deprivation condition.
Title: SH2B1 protects against OGD/R‑induced apoptosis in PC12 cells via activation of the JAK2/STAT3 signaling pathway.
These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching.
Title: SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches.
findings demonstrate that SH2B1beta promotes BDNF-induced neurite outgrowth through enhancing pathways involved MEK-ERK1/2 and PI3K-AKT.
Title: New function of the adaptor protein SH2B1 in brain-derived neurotrophic factor-induced neurite outgrowth.
Long-Evans rats maintained on chow or a high-fat diet (HFD) for 6 weeks. From a total of 19 genes analyzed, seven genes (ETV5, FTO, GNPDA2, KCTD15, TMEM18, MC4R, and SH2B1) were down-regulated in the hypothalamus of HFD compared to chow-fed rats
Title: Expression of new loci associated with obesity in diet-induced obese rats: from genetics to physiology.
These findings provide significant new insights into how N-cadherin-mediated inter-cellular interactions may influence neurite initiation and how SH2B1beta may regulate these processes.
Title: SH2B1β regulates N-cadherin levels, cell-cell adhesion and nerve growth factor-induced neurite initiation.
SH2B1beta must shuttle between the plasma membrane and nucleus to function as a critical component of NGF-induced gene expression and neuronal differentiation.
Title: Nucleocytoplasmic shuttling of the adapter protein SH2B1beta (SH2-Bbeta) is required for nerve growth factor (NGF)-dependent neurite outgrowth and enhancement of expression of a subset of NGF-responsive genes.
SH2B1beta enhances FGF1-induced neurite outgrowth in PC12 cells mainly through MEK-ERK1/2-STAT3-Egr1 pathway.
Title: SH2B1beta enhances fibroblast growth factor 1 (FGF1)-induced neurite outgrowth through MEK-ERK1/2-STAT3-Egr1 pathway.
Results suggest that SH2B1beta stimulates NGF-induced neuronal differentiation at least in part by enhancing expression of a specific subset of NGF-sensitive genes, including Plaur, Mmp3, and/or Mmp10, required for neurite outgrowth.
Title: SH2B1beta (SH2-Bbeta) enhances expression of a subset of nerve growth factor-regulated genes important for neuronal differentiation including genes encoding urokinase plasminogen activator receptor and matrix metalloproteinase 3/10.
SH2-Bbeta and APS do not activate JAK2 as a consequence of their own dimerization, recruitment of an activator of JAK2, or direct competition with a JAK2 inhibitor for binding to JAK2. They most likely induce or stabilize an active conformation of JAK2.
Title: Binding of SH2-B family members within a potential negative regulatory region maintains JAK2 in an active state.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC133757P1 (e-PCR)
- UniSTS:270653

UniSTS:279423 (e-PCR)
- UniSTS:279423

Sh2b1 (e-PCR), detects polymorphism
- UniSTS:279423

AI425885 (e-PCR)
- UniSTS:179649

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell motility	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in lamellipodium assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: SH2B adapter protein 1

Names: SH2 domain-containing protein 1B; SH2-B PH domain-containing signaling mediator 1; fceRI gamma-chain-interacting protein SH2-B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048180.1 → NP_001041645.1 SH2B adapter protein 1 isoform 2

See identical proteins and their annotated locations for NP_001041645.1

Status: VALIDATED

Source sequence(s)

AAHX01008496, AF047577, AI029537, BM389529, U57391

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I967

Conserved Domains (3) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper
NM_134456.3 → NP_604451.2 SH2B adapter protein 1 isoform 1

See identical proteins and their annotated locations for NP_604451.2

Status: VALIDATED

Source sequence(s)

AF047577, AI029537, BM389529, CB742512, U57391

UniProtKB/Swiss-Prot

O55072, Q62985

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I961

Conserved Domains (4) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam00169
Location:312 → 376

PH; PH domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

190479211..190492030 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006230354.5 → XP_006230416.1 SH2B adapter protein 1 isoform X1

See identical proteins and their annotated locations for XP_006230416.1

UniProtKB/Swiss-Prot

O55072, Q62985

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I961

Conserved Domains (4) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam00169
Location:312 → 376

PH; PH domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper
XM_063276001.1 → XP_063132071.1 SH2B adapter protein 1 isoform X4

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I967
XM_063275992.1 → XP_063132062.1 SH2B adapter protein 1 isoform X2

UniProtKB/TrEMBL

A6I963, M0R617
XM_063275999.1 → XP_063132069.1 SH2B adapter protein 1 isoform X3

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I970
XM_063275993.1 → XP_063132063.1 SH2B adapter protein 1 isoform X3

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I970
XM_063275991.1 → XP_063132061.1 SH2B adapter protein 1 isoform X2

UniProtKB/TrEMBL

A6I963, M0R617
XM_039093107.2 → XP_038949035.1 SH2B adapter protein 1 isoform X2

UniProtKB/TrEMBL

A6I963, M0R617

Related

ENSRNOP00000066048.3, ENSRNOT00000074274.4

Conserved Domains (3) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper
XM_039093117.2 → XP_038949045.1 SH2B adapter protein 1 isoform X3

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I970

Related

ENSRNOP00000064854.3, ENSRNOT00000071241.5

Conserved Domains (3) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper
XM_006230353.5 → XP_006230415.1 SH2B adapter protein 1 isoform X1

See identical proteins and their annotated locations for XP_006230415.1

UniProtKB/Swiss-Prot

O55072, Q62985

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I961

Conserved Domains (4) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam00169
Location:312 → 376

PH; PH domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper
XM_063276000.1 → XP_063132070.1 SH2B adapter protein 1 isoform X4

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I967
XM_039093126.2 → XP_038949054.1 SH2B adapter protein 1 isoform X4

UniProtKB/TrEMBL

A0A8L2QYJ5, A6I967

Conserved Domains (3) summary

cd10346
Location:518 → 614

SH2_SH2B_family; Src homology 2 (SH2) domain found in SH2B adapter protein family

cd01231
Location:247 → 378

PH_SH2B_family; SH2B adapter protein 1, 2, and 3 Pleckstrin homology (PH) domain

pfam08916
Location:26 → 81

Phe_ZIP; Phenylalanine zipper