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    Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 192260, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cdiptprovided by RGD
    Official Full Name
    CDP-diacylglycerol--inositol 3-phosphatidyltransferaseprovided by RGD
    Primary source
    RGD:620576
    See related
    EnsemblRapid:ENSRNOG00000024144 AllianceGenome:RGD:620576
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Pis; Pis1
    Summary
    Enables several functions, including CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity; diacylglycerol binding activity; and manganese ion binding activity. Involved in CDP-diacylglycerol metabolic process and phosphatidylinositol biosynthetic process. Predicted to be located in membrane. Predicted to be active in Golgi apparatus. Orthologous to human CDIPT (CDP-diacylglycerol--inositol 3-phosphatidyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 223.7), Brain (RPKM 215.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cdipt in Genome Data Viewer
    Location:
    1q37
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (191013632..191017943)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (181583098..181587409)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (198409186..198413497)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene seizure related 6 homolog like 2 Neighboring gene CDIP transferase, opposite strand Neighboring gene major vault protein Neighboring gene Paxip1-associated glutamate-rich protein 1 Neighboring gene proline-rich transmembrane protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning of rat phosphatidylinositol synthase cDNA by functional complementation of the yeast Saccharomyces cerevisiae pis mutation. Tanaka S, et al. FEBS Lett, 1996 Sep 9. PMID 8804431
    2. Identification of rat liver phosphatidylinositol synthase as a 21 kDa protein. Monaco ME, et al. Biochem J, 1994 Nov 15. PMID 7998949, Free PMC Article
    3. Regulation by phosphatidylinositol of rat pituitary plasma membrane and endoplasmic reticulum phosphatidylinositol synthase activities. A mechanism for activation of phosphoinositide resynthesis during cell stimulation. Imai A, et al. J Biol Chem, 1987 May 15. PMID 3032971
    4. Purification and characterization of phosphatidylinositol synthase from human placenta. Antonsson BE. Biochem J, 1994 Feb 1. PMID 8110188, Free PMC Article
    5. The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content. Lykidis A, et al. J Biol Chem, 1997 Dec 26. PMID 9407135

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alcohol binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables carbohydrate binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables diacylglycerol binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CDP-diacylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylinositol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CDP-diacylglycerol--inositol 3-phosphatidyltransferase
    Names
    PI synthase
    phosphatidylinositol synthase
    ptdIns synthase
    NP_620254.1
    XP_006230270.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_138899.2 → NP_620254.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase

      See identical proteins and their annotated locations for NP_620254.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070876
      UniProtKB/Swiss-Prot
      P70500
      UniProtKB/TrEMBL
      A6I9J7
      Related
      ENSRNOP00000070871.1, ENSRNOT00000091295.3
      Conserved Domains (1) summary
      pfam01066
      Location:10 → 72
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      191013632..191017943
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006230208.1 → XP_006230270.1  CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006230270.1

      UniProtKB/Swiss-Prot
      P70500
      UniProtKB/TrEMBL
      A6I9J7
      Conserved Domains (1) summary
      pfam01066
      Location:10 → 72
      CDP-OH_P_transf; CDP-alcohol phosphatidyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70500.1 GenPept UniProtKB/Swiss-Prot:P70500

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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