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    SCAB1 plectin-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817218, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCAB1
    Official Full Name
    plectin-like protein
    Primary source
    TAIR:AT2G26770
    Locus tag
    AT2G26770
    See related
    Araport:AT2G26770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18A8.14; F18A8_14; stomatal closure-related actin binding protein 1
    Summary
    Encodes a plant-specific actin binding protein SCAB1 (STOMATAL CLOSURE-RELATED ACTIN BINDING PROTEIN1). SCAB1 stabilizes actin filaments and regulates stomatal movement.
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    Genomic context

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    See SCAB1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    14
    Sequence:
    Chromosome: 2; NC_003071.7 (11403979..11408421, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene Cyclin B1;4 Neighboring gene ncRNA Neighboring gene ARM repeat superfamily protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SCAB1 coordinates sequential Ca(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis. Zhang T, et al. Sci China Life Sci, 2024 Jan. PMID 38153680
    2. Phosphatidylinositol 3-phosphate regulates SCAB1-mediated F-actin reorganization during stomatal closure in Arabidopsis. Yang Y, et al. Plant Cell, 2022 Jan 20. PMID 34850207, Free PMC Article
    3. Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain. Zhang W, et al. J Biol Chem, 2012 Apr 6. PMID 22356912, Free PMC Article
    4. The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis. Zhao Y, et al. Plant Cell, 2011 Jun. PMID 21719691, Free PMC Article
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCAB1 coordinates sequential Ca[2+] and ABA signals during osmotic stress induced stomatal closure in Arabidopsis.
      Title: SCAB1 coordinates sequential Ca(2+) and ABA signals during osmotic stress induced stomatal closure in Arabidopsis.
    2. Phosphatidylinositol 3-phosphate regulates SCAB1-mediated F-actin reorganization during stomatal closure in Arabidopsis.
      Title: Phosphatidylinositol 3-phosphate regulates SCAB1-mediated F-actin reorganization during stomatal closure in Arabidopsis.
    3. SCAB1 is a novel plant-specific actin-binding protein that binds, bundles, and stabilizes actin filaments and regulates stomatal movement. [SCAB1]
      Title: Plant actin-binding protein SCAB1 is dimeric actin cross-linker with atypical pleckstrin homology domain.
    4. SCAB1 is required for the precise regulation of actin filament reorganization during stomatal closure. [SCAB1]
      Title: The plant-specific actin binding protein SCAB1 stabilizes actin filaments and regulates stomatal movement in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336082.1
    NM_128234.4
    NM_179754.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin filament organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    plectin-like protein
    NP_180245.1
    • plectin-related; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G40820.1); Has 4721 Blast hits to 4136 proteins in 536 species: Archae - 91; Bacteria - 672; Metazoa - 2162; Fungi - 328; Plants - 350; Viruses - 13; Other Eukaryotes - 1105 (source: NCBI BLink).
    NP_850085.1
    • plectin-related; BEST Arabidopsis thaliana protein match is: unknown protein (TAIR:AT2G40820.1); Has 4722 Blast hits to 4137 proteins in 536 species: Archae - 91; Bacteria - 673; Metazoa - 2162; Fungi - 328; Plants - 350; Viruses - 13; Other Eukaryotes - 1105 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11403979..11408421 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179754.2 → NP_850085.1  plectin-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850085.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48791
      UniProtKB/TrEMBL
      A0A178VYU3, A0A7G2EBD0
      Conserved Domains (4) summary
      pfam16711
      Location:55 → 95
      SCAB-ABD; Actin-binding domain of plant-specific actin-binding protein
      pfam16709
      Location:281 → 378
      SCAB-IgPH; Fused Ig-PH domain of plant-specific actin-binding protein
      pfam16712
      Location:100 → 267
      SCAB_CC; Coiled-coil regions of plant-specific actin-binding protein
      pfam17684
      Location:381 → 488
      SCAB-PH; PH domain of plant-specific actin-binding protein

    2. NM_128234.4 → NP_180245.1  plectin-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48791
      UniProtKB/TrEMBL
      A0A178VYU3, A0A7G2EBD0
      Conserved Domains (4) summary
      pfam16711
      Location:55 → 95
      SCAB-ABD; Actin-binding domain of plant-specific actin-binding protein
      pfam16709
      Location:281 → 378
      SCAB-IgPH; Fused Ig-PH domain of plant-specific actin-binding protein
      pfam16712
      Location:100 → 267
      SCAB_CC; Coiled-coil regions of plant-specific actin-binding protein
      pfam17684
      Location:381 → 488
      SCAB-PH; PH domain of plant-specific actin-binding protein

    3. NM_001336082.1 → NP_001323795.1  plectin-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48791
      UniProtKB/TrEMBL
      A0A178VYU3, A0A7G2EBD0
      Conserved Domains (4) summary
      pfam16711
      Location:55 → 95
      SCAB-ABD; Actin-binding domain of plant-specific actin-binding protein
      pfam16709
      Location:281 → 378
      SCAB-IgPH; Fused Ig-PH domain of plant-specific actin-binding protein
      pfam16712
      Location:100 → 267
      SCAB_CC; Coiled-coil regions of plant-specific actin-binding protein
      pfam17684
      Location:381 → 488
      SCAB-PH; PH domain of plant-specific actin-binding protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48791.1

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