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    ROPGAP3 Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 819283, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ROPGAP3
    Official Full Name
    Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein
    Primary source
    TAIR:AT2G46710
    Locus tag
    AT2G46710
    See related
    Araport:AT2G46710
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ROP guanosine triphosphatase (GTPase)-activating protein 3; T3A4.9
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    Genomic context

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    See ROPGAP3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (19191247..19195093)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene CDPK-related kinase 3 Neighboring gene ncRNA Neighboring gene 3-ketoacyl-CoA synthase 13 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis RopGAPs are a novel family of rho GTPase-activating proteins that require the Cdc42/Rac-interactive binding motif for rop-specific GTPase stimulation. Wu G, et al. Plant Physiol, 2000 Dec. PMID 11115880, Free PMC Article
    2. A Rho-based reaction-diffusion system governs cell wall patterning in metaxylem vessels. Nagashima Y, et al. Sci Rep, 2018 Aug 1. PMID 30069009, Free PMC Article
    3. Initiation of cell wall pattern by a Rho- and microtubule-driven symmetry breaking. Oda Y, et al. Science, 2012 Sep 14. PMID 22984069
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_180127.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within plant-type cell wall organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in secondary cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein
    NP_850458.1
    • Rho GTPase activating protein with PAK-box/P21-Rho-binding domain; FUNCTIONS IN: Rac GTPase activator activity; INVOLVED IN: signal transduction; LOCATED IN: intracellular; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: PAK-box/P21-Rho-binding (InterPro:IPR000095), Rho GTPase activation protein (InterPro:IPR008936), RhoGAP (InterPro:IPR000198); BEST Arabidopsis thaliana protein match is: Rho GTPase activating protein with PAK-box/P21-Rho-binding domain (TAIR:AT4G03100.1); Has 3093 Blast hits to 3092 proteins in 169 species: Archae - 0; Bacteria - 0; Metazoa - 2259; Fungi - 327; Plants - 185; Viruses - 0; Other Eukaryotes - 322 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      19191247..19195093
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180127.2 → NP_850458.1  Rho GTPase activating protein with PAK-box/P21-Rho-binding domain-containing protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GYY5, Q9ZUZ1
      UniProtKB/TrEMBL
      A0A178VSX4, A0A5S9X7M4, A0A654F3W1
      Conserved Domains (2) summary
      cd00132
      Location:103 → 143
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd00159
      Location:167 → 323
      RhoGAP; GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GYY5.1

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