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    EER5 proteasome family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816475, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EER5
    Official Full Name
    proteasome family protein
    Primary source
    TAIR:AT2G19560
    Locus tag
    AT2G19560
    See related
    Araport:AT2G19560
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtTHP1; ectopic expression of seed storage proteins 1; ENHANCED ETHYLENE RESPONSE 5; ESSP1; F3P11.16; F3P11_16
    Summary
    encodes a protein with a PAM domain involved in ethylene signaling. eer5 mutants show ethylene hypersensitivity in relation to hypocotyl elongation. EER5 interacts with EIN2 and with COP9 in Y2H assays. EIN3 protein levels are the same in WT and eer5-1 mutants. EER5 may be involved in promoting a dampening of the ethylene response.
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    Genomic context

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    See EER5 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Sequence:
    Chromosome: 2; NC_003071.7 (8465690..8469145, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Transducin family protein / WD-40 repeat family protein Neighboring gene alpha/beta-Hydrolases superfamily protein Neighboring gene ncRNA Neighboring gene cytidine deaminase 1 Neighboring gene tetraspanin2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The eer5 mutation, which affects a novel proteasome-related subunit, indicates a prominent role for the COP9 signalosome in resetting the ethylene-signaling pathway in Arabidopsis. Christians MJ, et al. Plant J, 2008 Aug. PMID 18429939
    2. Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis. Deslauriers SD, et al. New Phytol, 2015 Oct. PMID 25988998
    3. Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin. Lu Q, et al. Plant J, 2010 Jan. PMID 19843313
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data identified EER5 (At2g19560) as ESSP1, and referred to ESSP1 as AtTHP1, a component of nuclear pore complexes.
      Title: Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin.
    2. The EER5 protein serves as a bridge between EIN2 and the modification or degradation of target proteins, including a proposed group of transcriptional repressors, as part of a resetting mechanism during or following ethylene signaling. [EER5]
      Title: The eer5 mutation, which affects a novel proteasome-related subunit, indicates a prominent role for the COP9 signalosome in resetting the ethylene-signaling pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001335638.1
    NM_127514.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within ethylene-activated signaling pathway IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in poly(A)+ mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within poly(A)+ mRNA export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to ethylene IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome family protein
    NP_179546.2
    • ENHANCED ETHYLENE RESPONSE 5 (EER5); CONTAINS InterPro DOMAIN/s: Proteasome component (PCI) domain (InterPro:IPR000717), PCI/PINT associated module (InterPro:IPR013143); Has 771 Blast hits to 770 proteins in 220 species: Archae - 0; Bacteria - 0; Metazoa - 260; Fungi - 323; Plants - 58; Viruses - 0; Other Eukaryotes - 130 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      8465690..8469145 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127514.4 → NP_179546.2  proteasome family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179546.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8GWE6, Q9ZUN6
      UniProtKB/TrEMBL
      A0A178VT20, A0A5S9WZN3
      Conserved Domains (1) summary
      cl02111
      Location:15 → 406
      PCI; PCI domain

    2. NM_001335638.1 → NP_001324728.1  proteasome family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B105
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8GWE6.1

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