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    NAD(P)-binding Rossmann-fold superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837570, updated on 18-Sep-2024

    Summary

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    Official Full Name
    NAD(P)-binding Rossmann-fold superfamily protein
    Primary source
    TAIR:AT1G10310
    Locus tag
    AT1G10310
    See related
    Araport:AT1G10310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F14N23.19; F14N23_19
    Summary
    encodes a NADPH-dependent pterin aldehyde reductase that accepts pterin aldehyde as well as dihydropterin aldehyde as substrates involved in metabolism and salvage of folate and its derivatives.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (3381447..3384003, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene dynamin-like protein 6 Neighboring gene Nucleolar GTP-binding protein Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases. Noiriel A, et al. Plant J, 2007 Aug. PMID 17550420
    2. Conserved and plant-specific histone acetyltransferase complexes cooperate to regulate gene transcription and plant development. Wu CJ, et al. Nat Plants, 2023 Mar. PMID 36879016
    3. Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project. Ajjawi I, et al. Plant Physiol, 2010 Feb. PMID 19906890, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of gene At1g10310 causes decreased seed 18:19 delta9 fatty acids.
      Title: Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project.
    2. typical of the generalist NADPH-linked reductases required for pterin aldehyde salvage in plants
      Title: Folate salvage in plants: pterin aldehyde reduction is mediated by multiple non-specific aldehyde reductases.
    Submit: New GeneRIF Correction

    General gene information

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    NM_100905.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within folic acid-containing compound metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD(P)-binding Rossmann-fold superfamily protein
    NP_563866.1
    • NAD(P)-binding Rossmann-fold superfamily protein; CONTAINS InterPro DOMAIN/s: Short-chain dehydrogenase/reductase, conserved site (InterPro:IPR020904), NAD(P)-binding domain (InterPro:IPR016040), Glucose/ribitol dehydrogenase (InterPro:IPR002347), Short-chain dehydrogenase/reductase SDR (InterPro:IPR002198); BEST Arabidopsis thaliana protein match is: NAD(P)-binding Rossmann-fold superfamily protein (TAIR:AT3G55290.2); Has 116138 Blast hits to 115933 proteins in 3618 species: Archae - 897; Bacteria - 77623; Metazoa - 6898; Fungi - 5998; Plants - 2845; Viruses - 2; Other Eukaryotes - 21875 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3381447..3384003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100905.4 → NP_563866.1  NAD(P)-binding Rossmann-fold superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563866.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LA87, Q9SY73
      UniProtKB/TrEMBL
      A0A178WMY3, A0A5S9TP45
      Conserved Domains (1) summary
      cd05233
      Location:20 → 205
      SDR_c; classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SY73.1

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