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    MC5 metacaspase 5 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 844271, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MC5
    Official Full Name
    metacaspase 5
    Primary source
    TAIR:AT1G79330
    Locus tag
    AT1G79330
    See related
    Araport:AT1G79330
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AMC6; ATMC5; ATMCP2b; ATMCP2B; MCP2b; metacaspase 2b; metacaspase 5; YUP8H12R.5; YUP8H12R_5
    Summary
    Metacaspase AtMCPb2/AMC6. Caspase family protein. Arginine/lysine-specific cysteine protease activity. Induces apoptosis in yeast. Contains Pfam domain, PF00656: ICE-like protease (caspase) p20 domain. Arabidopsis contains three type I MCP genes (MCP1a-c) and six type II MCP genes (MCP2a#Aeif): AtMCP1a/At5g64240, AtMCP1b/At1g02170, AtMCP1c/At4g25110, AtMCP2a/At1g79310, AtMCP2b/At1g79330, AtMCP2c/At1g79320, AtMCP2d/At1g79340, AtMCP2e/At1g16420, AtMCP2f/At5g04200.
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    Genomic context

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    See MC5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (29838551..29840317)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene metacaspase 7 Neighboring gene metacaspase 6 Neighboring gene miscRNA Neighboring gene metacaspase 4 Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene organic cation/carnitine transporter 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterising the Gene Expression, Enzymatic Activity and Subcellular Localisation of Arabidopsis thaliana Metacaspase 5 (AtMCA-IIb). Sobri ZM, et al. Biology (Basel), 2023 Aug 22. PMID 37759555, Free PMC Article
    2. Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast. Watanabe N, et al. J Biol Chem, 2005 Apr 15. PMID 15691845
    3. Sorting signals, N-terminal modifications and abundance of the chloroplast proteome. Zybailov B, et al. PLoS One, 2008 Apr 23. PMID 18431481, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases with roles in apoptosis. [AtMCP2b]
      Title: Two Arabidopsis metacaspases AtMCP1b and AtMCP2b are arginine/lysine-specific cysteine proteases and activate apoptosis-like cell death in yeast.
    Submit: New GeneRIF Correction

    General gene information

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    NM_106581.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of programmed cell death IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metacaspase 5
    NP_178051.1
    • metacaspase 5 (MC5); FUNCTIONS IN: cysteine-type endopeptidase activity; INVOLVED IN: induction of apoptosis; LOCATED IN: chloroplast; EXPRESSED IN: root; CONTAINS InterPro DOMAIN/s: Peptidase C14, caspase catalytic (InterPro:IPR011600); BEST Arabidopsis thaliana protein match is: metacaspase 4 (TAIR:AT1G79340.1); Has 1246 Blast hits to 1206 proteins in 288 species: Archae - 3; Bacteria - 374; Metazoa - 2; Fungi - 283; Plants - 322; Viruses - 0; Other Eukaryotes - 262 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      29838551..29840317
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_106581.3 → NP_178051.1  metacaspase 5 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_178051.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64518
      UniProtKB/TrEMBL
      A0A178WIC7, A0A5S9WVR7, A0A654F185
      Conserved Domains (1) summary
      pfam00656
      Location:3 → 170
      Peptidase_C14; Caspase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O64518.1

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