PARP1 poly(ADP-ribose) polymerase 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: PARP1
Official Full Name: poly(ADP-ribose) polymerase 2
Primary source: TAIR:AT2G31320
Locus tag: AT2G31320
See related: Araport:AT2G31320
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATPARP2; F16D14.16; F16D14_16; POLY(ADP-RIBOSE) POLYMERASE 1; poly(ADP-ribose) polymerase 2
Summary: Encodes a poly(ADP-ribose) polymerase.
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Genomic context

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See PARP1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 19

Sequence:: Chromosome: 2; NC_003071.7 (13353748..13359750, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AtPARP3 has lost poly (ADP-ribose) polymerase activity in plants and performs different functions from those of AtPARP1 and AtPARP2. AtPARP1, instead of AtPARP2, plays the predominant role in PAR synthesis in both seeds and seedlings.
Title: New perspectives on the plant PARP family: Arabidopsis PARP3 is inactive, and PARP1 exhibits predominant poly (ADP-ribose) polymerase activity in response to DNA damage.
We found that larger deletions of >20 bp predominated after DSB repair in ku80 and ku80 parp1 parp2 mutants, corroborating with a role of KU in preventing DSB end resection. Deletion lengths did not significantly differ between ku80 and ku80 parp1 parp2 mutants, suggesting that a KU- and PARP-independent b-NHEJ mechanism becomes active in these mutants.
Title: CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants.
whilst all isoforms of PARP were localized to the nucleus they are also present in non-nuclear locations with parp1 and parp3 also localised in the cytosol, and parp2 also present in the mitochondria
Title: Analysis of knockout mutants reveals non-redundant functions of poly(ADP-ribose)polymerase isoforms in Arabidopsis.
Studies indicate that a massive and rapid accumulation of a massive and rapid accumulation poly(ADP-ribose) polymerases AtPARP1 and AtPARP2 transcripts was observed upon treatment with ionizing radiation and reactive oxigen species (ROS).
Title: Synthesis and degradation of poly(ADP-ribose) in plants.
PARP isoforms play a minor role in telomere length maintenance in Arabidopsis.
Title: Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology.
Evidence suggests a link between the glutathione pool and PARP expression and activity that is perhaps related to the distribution of intracellular glutathione between the cytoplasm and the nucleus. [PARP1]
Title: Pyridine nucleotide cycling and control of intracellular redox state in relation to poly (ADP-ribose) polymerase activity and nuclear localization of glutathione during exponential growth of Arabidopsis cells in culture.
in PARP2-deficient Arabidopsis plants, the observed abiotic stress resistance can also be explained by alterations in abscisic acid levels that facilitate the induction of a wide set of defense-related genes
Title: Silencing of poly(ADP-ribose) polymerase in plants alters abiotic stress signal transduction.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_179834.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA repair	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within protein poly-ADP-ribosylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: poly(ADP-ribose) polymerase 2

NP_850165.1

poly(ADP-ribose) polymerase 2 (PARP2); FUNCTIONS IN: NAD+ ADP-ribosyltransferase activity, NAD or NADH binding, DNA binding, zinc ion binding; INVOLVED IN: DNA repair, response to oxidative stress, response to abscisic acid stimulus, protein amino acid ADP-ribosylation, response to abiotic stimulus; LOCATED IN: intracellular, nucleus; EXPRESSED IN: 20 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: PADR1 (InterPro:IPR012982), Zinc finger, PARP-type (InterPro:IPR001510), WGR (InterPro:IPR008893), Poly(ADP-ribose) polymerase, regulatory domain (InterPro:IPR004102), NAD+ ADP-ribosyltransferase (InterPro:IPR008288), Poly(ADP-ribose) polymerase, catalytic domain (InterPro:IPR012317), BRCT (InterPro:IPR001357); BEST Arabidopsis thaliana protein match is: NAD+ ADP-ribosyltransferases;NAD+ ADP-ribosyltransferases (TAIR:AT5G22470.1); Has 1243 Blast hits to 1018 proteins in 163 species: Archae - 0; Bacteria - 14; Metazoa - 746; Fungi - 100; Plants - 173; Viruses - 2; Other Eukaryotes - 208 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

13353748..13359750 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_179834.2 → NP_850165.1 poly(ADP-ribose) polymerase 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850165.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SJW4, Q9ZP54

UniProtKB/TrEMBL

A0A654F8H1

Conserved Domains (6) summary

cd08001
Location:512 → 618

WGR_PARP1_like; WGR domain of poly(ADP-ribose) polymerase 1 and similar proteins

smart00292
Location:399 → 471

BRCT; breast cancer carboxy-terminal domain

PLN03123
Location:1 → 983

PLN03123; poly [ADP-ribose] polymerase; Provisional

cd01437
Location:634 → 978

parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...

pfam00645
Location:11 → 85

zf-PARP; Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region

pfam08063
Location:291 → 342

PADR1; PADR1 (NUC008) domain