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    EME1A essential meiotic endonuclease 1A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816716, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EME1A
    Official Full Name
    essential meiotic endonuclease 1A
    Primary source
    TAIR:AT2G21800
    Locus tag
    AT2G21800
    See related
    Araport:AT2G21800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATEME1A; essential meiotic endonuclease 1A; F7D8.12; F7D8_12
    Summary
    Forms a complex with MUS81 that functions as endonuclease in DNA recombination and repair processes.
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    Genomic context

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    See EME1A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (9298078..9301926)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ribonucleotide reductase 1 Neighboring gene Cysteine/Histidine-rich C1 domain family protein Neighboring gene seed maturation protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two distinct MUS81-EME1 complexes from Arabidopsis process Holliday junctions. Geuting V, et al. Plant Physiol, 2009 Jun. PMID 19339504, Free PMC Article
    2. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_001202643.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA recombination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within DNA repair IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of Holliday junction resolvase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    essential meiotic endonuclease 1A
    NP_001189572.1
    • essential meiotic endonuclease 1A (EME1A); CONTAINS InterPro DOMAIN/s: ERCC4 domain (InterPro:IPR006166); BEST Arabidopsis thaliana protein match is: essential meiotic endonuclease 1B (TAIR:AT2G22140.1).
    NP_179771.2
    • essential meiotic endonuclease 1A (EME1A); CONTAINS InterPro DOMAIN/s: ERCC4 domain (InterPro:IPR006166); BEST Arabidopsis thaliana protein match is: essential meiotic endonuclease 1B (TAIR:AT2G22140.1); Has 2270 Blast hits to 1760 proteins in 250 species: Archae - 0; Bacteria - 114; Metazoa - 736; Fungi - 365; Plants - 159; Viruses - 22; Other Eukaryotes - 874 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9298078..9301926
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127749.5 → NP_179771.2  essential meiotic endonuclease 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179771.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C5IHG3, Q84M98, Q9SJ19
      UniProtKB/TrEMBL
      A0A5S9X081, A0A654EUX0
      Conserved Domains (2) summary
      pfam00836
      Location:175 → 238
      Stathmin; Stathmin family
      pfam02732
      Location:249 → 406
      ERCC4; ERCC4 domain

    2. NM_001335775.1 → NP_001323848.1  essential meiotic endonuclease 1A [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYE0, A0A5S9X081, A0A654EUX0

    3. NM_001202643.1 → NP_001189572.1  essential meiotic endonuclease 1A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189572.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X081, A0A654EUX0
      Conserved Domains (2) summary
      pfam00836
      Location:175 → 238
      Stathmin; Stathmin family
      pfam02732
      Location:249 → 409
      ERCC4; ERCC4 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84M98.1

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