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    MGDC monogalactosyldiacylglycerol synthase type C [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 815657, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MGDC
    Official Full Name
    monogalactosyldiacylglycerol synthase type C
    Primary source
    TAIR:AT2G11810
    Locus tag
    AT2G11810
    See related
    Araport:AT2G11810
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATMGD3; F7E22.4; F7E22_4; MGD3; MONOGALACTOSYL DIACYLGLYCEROL SYNTHASE 3; MONOGALACTOSYL DIACYLGLYCEROL SYNTHASE 3; MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE; monogalactosyldiacylglycerol synthase type C
    Summary
    MGD3 is the major enzyme for galactolipid metabolism during phosphate starvation. Does not contribute to galactolipid synthesis under P1-sufficient conditions.
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    Genomic context

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    See MGDC in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (4743162..4746813)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Type-B monogalactosyldiacylglycerol synthases are involved in phosphate starvation-induced lipid remodeling, and are crucial for low-phosphate adaptation. Kobayashi K, et al. Plant J, 2009 Jan. PMID 18808455
    2. Membrane lipid alteration during phosphate starvation is regulated by phosphate signaling and auxin/cytokinin cross-talk. Kobayashi K, et al. Plant J, 2006 Jul. PMID 16762032
    3. Two types of MGDG synthase genes, found widely in both 16:3 and 18:3 plants, differentially mediate galactolipid syntheses in photosynthetic and nonphotosynthetic tissues in Arabidopsis thaliana. Awai K, et al. Proc Natl Acad Sci U S A, 2001 Sep 11. PMID 11553816, Free PMC Article
    4. An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response. Carianopol CS, et al. Commun Biol, 2020 Mar 26. PMID 32218501, Free PMC Article
    5. A mesoscale abscisic acid hormone interactome reveals a dynamic signaling landscape in Arabidopsis. Lumba S, et al. Dev Cell, 2014 May 12. PMID 24823379

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MGD3 plays a crucial role in membrane lipid remodeling during Pi starvation.
      Title: Type-B monogalactosyldiacylglycerol synthases are involved in phosphate starvation-induced lipid remodeling, and are crucial for low-phosphate adaptation.
    2. Exogenous auxin activates MGD3 expression during Phosphate starvation, whereas expression is repressed by cytokinin treatment in the root.
      Title: Membrane lipid alteration during phosphate starvation is regulated by phosphate signaling and auxin/cytokinin cross-talk.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001124829.2
    NM_001335375.1
    NM_126865.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1,2-diacylglycerol 3-beta-galactosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 1,2-diacylglycerol 3-beta-galactosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hexosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to phosphate starvation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within galactolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycolipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monogalactosyldiacylglycerol synthase type C
    NP_001118301.1
    • monogalactosyldiacylglycerol synthase type C (MGDC); CONTAINS InterPro DOMAIN/s: Monogalactosyldiacylglycerol synthase (InterPro:IPR009695); BEST Arabidopsis thaliana protein match is: monogalactosyldiacylglycerol synthase 2 (TAIR:AT5G20410.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_565352.1
    • monogalactosyldiacylglycerol synthase type C (MGDC); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 28, C-terminal (InterPro:IPR007235), Monogalactosyldiacylglycerol synthase (InterPro:IPR009695); BEST Arabidopsis thaliana protein match is: monogalactosyldiacylglycerol synthase 2 (TAIR:AT5G20410.1); Has 2157 Blast hits to 2157 proteins in 790 species: Archae - 0; Bacteria - 1916; Metazoa - 0; Fungi - 0; Plants - 110; Viruses - 0; Other Eukaryotes - 131 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      4743162..4746813
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001335374.1 → NP_001323965.1  monogalactosyldiacylglycerol synthase type C [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYN0

    2. NM_126865.5 → NP_565352.1  monogalactosyldiacylglycerol synthase type C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565352.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B3H4P3, Q9FZL5, Q9SI93, W8PV29
      UniProtKB/TrEMBL
      A0A654F3E6
      Conserved Domains (3) summary
      PLN02605
      Location:75 → 454
      PLN02605; monogalactosyldiacylglycerol synthase
      pfam06925
      Location:86 → 254
      MGDG_synth; Monogalactosyldiacylglycerol (MGDG) synthase
      cl10013
      Location:247 → 445
      Glycosyltransferase_GTB_type; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate ...

    3. NM_001124829.2 → NP_001118301.1  monogalactosyldiacylglycerol synthase type C [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118301.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SI93
      Conserved Domains (2) summary
      PLN02605
      Location:75 → 361
      PLN02605; monogalactosyldiacylglycerol synthase
      pfam06925
      Location:86 → 254
      MGDG_synth; Monogalactosyldiacylglycerol (MGDG) synthase

    4. NM_001335375.1 → NP_001323966.1  monogalactosyldiacylglycerol synthase type C [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYS3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SI93.2

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