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    FKGP L-fucokinase/GDP-L-fucose pyrophosphorylase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839420, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FKGP
    Official Full Name
    L-fucokinase/GDP-L-fucose pyrophosphorylase
    Primary source
    TAIR:AT1G01220
    Locus tag
    AT1G01220
    See related
    Araport:AT1G01220
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    Arabidopsis thaliana L-fucokinase/GDP-L-fucose pyrophosphorylase; AtFKGP; F6F3.3; F6F3_3; L-fucokinase/GDP-L-fucose pyrophosphorylase
    Summary
    Encodes a bifunctional enzyme that has both L-fucokinase and GDP-L-fucose pyrophosphorylase activities. It catalyzes the two steps of the L-fucose salvage pathway for the generation of activated GDP-L-fucose. This pathway seems to be of minor importance for cell wall polysaccharide biosynthesis compared to the de novo GDP-L-fucose biosynthesis pathway in Arabidopsis.
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    Genomic context

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    See FKGP in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (91342..95681)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RAB GTPase homolog A3 Neighboring gene DNA-directed RNA polymerase, subunit M, archaeal Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene NC domain-containing protein-like protein Neighboring gene ORMDL family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis. Kotake T, et al. J Biol Chem, 2008 Mar 28. PMID 18199744
    2. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtFKGP is a bifunctional enzyme with L-fucokinase and GDP-L-Fuc pyrophosphorylase activities, which salvages free L-Fuc in Arabidopsis
      Title: A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001331259.1
    NM_001331260.1
    NM_001331261.1
    NM_001331262.1
    NM_100004.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables fucokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fucose-1-phosphate guanylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within GDP-L-fucose salvage IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    L-fucokinase/GDP-L-fucose pyrophosphorylase
    NP_563620.1
    • L-fucokinase/GDP-L-fucose pyrophosphorylase (FKGP); FUNCTIONS IN: fucose-1-phosphate guanylyltransferase activity, fucokinase activity, ATP binding, galactokinase activity; INVOLVED IN: GDP-L-fucose salvage; LOCATED IN: cytoplasm; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Mevalonate/galactokinase (InterPro:IPR006206), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568), GHMP kinase (InterPro:IPR006204), L-fucokinase (InterPro:IPR012887), Ribosomal protein S5 domain 2-type fold, subgroup (InterPro:IPR014721), GHMP kinase, C-terminal (InterPro:IPR013750); Has 1878 Blast hits to 1819 proteins in 539 species: Archae - 59; Bacteria - 918; Metazoa - 155; Fungi - 3; Plants - 87; Viruses - 3; Other Eukaryotes - 653 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      91342..95681
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331256.1 → NP_001320981.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APH1, A0A7G2DTB6

    2. NM_001331257.1 → NP_001320980.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8API3, A0A654E739

    3. NM_001331258.1 → NP_001320985.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6Y3, A0A1P8APH6, A0A384LK65, A0A654E739
      Conserved Domains (2) summary
      PRK13412
      Location:19 → 935
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:24 → 422
      Fucokinase; L-fucokinase

    4. NM_100004.4 → NP_563620.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_563620.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNJ9
      UniProtKB/TrEMBL
      A0A5S9S1M5, A0A654E739
      Conserved Domains (2) summary
      PRK13412
      Location:32 → 1042
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:131 → 529
      Fucokinase; L-fucokinase

    5. NM_001331259.1 → NP_001320984.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APH1, A0A7G2DTB6

    6. NM_001331260.1 → NP_001320983.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8APH1, A0A7G2DTB6

    7. NM_001331261.1 → NP_001320982.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9LNJ9
      UniProtKB/TrEMBL
      A0A5S9S1M5, A0A654E739
      Conserved Domains (2) summary
      PRK13412
      Location:32 → 1042
      fkp; bifunctional fucokinase/L-fucose-1-P-guanylyltransferase; Provisional
      pfam07959
      Location:131 → 529
      Fucokinase; L-fucokinase

    8. NM_001331262.1 → NP_001320979.1  L-fucokinase/GDP-L-fucose pyrophosphorylase [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8API3, A0A654E739
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LNJ9.2

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