NADK1 NAD kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: NADK1
Official Full Name: NAD kinase 1
Primary source: TAIR:AT3G21070
Locus tag: AT3G21070
See related: Araport:AT3G21070
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATNADK-1; NAD kinase 1; NAD KINASE 1
Summary: Encodes a protein with NAD(H) kinase activity.
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Genomic context

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See NADK1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 11

Sequence:: Chromosome: 3; NC_003074.8 (7380191..7384163, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The subcellular distribution of the three NADK isoforms was examined using NADK-green fluorescent protein (GFP) fusion proteins expressed transiently in Arabidopsis suspension-cultured cells.
Title: Subcellular and tissue localization of NAD kinases from Arabidopsis: compartmentalization of de novo NADP biosynthesis.
Arabidopsis thaliana gene NADK-1 encodes a NAD(H) kinase that may contribute to the maintenance of redox status. [AtNADK-1]
Title: Stress induces the expression of AtNADK-1, a gene encoding a NAD(H) kinase in Arabidopsis thaliana.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001338499.1

Supported by ESTs:

NM_001338500.1

Supported by ESTs:

NM_001338501.1

Supported by ESTs:

NM_202618.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables NAD+ kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables NAD+ kinase activity	IEA Inferred from Electronic Annotation more info
enables NADH kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables NADH kinase activity	IEA Inferred from Electronic Annotation more info
NOT enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in NAD metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within NADP biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within phosphorylation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: NAD kinase 1

NP_001319603.1

NAD kinase 1 (NADK1); FUNCTIONS IN: NAD+ kinase activity, NADH kinase activity; INVOLVED IN: NADP biosynthetic process, response to virus, response to hydrogen peroxide, pyridine nucleotide biosynthetic process, response to ionizing radiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 2 (TAIR:AT1G21640.1); Has 7879 Blast hits to 7861 proteins in 2677 species: Archae - 264; Bacteria - 5251; Metazoa - 207; Fungi - 397; Plants - 118; Viruses - 0; Other Eukaryotes - 1642 (source: NCBI BLink).

NP_974347.1

NAD kinase 1 (NADK1); FUNCTIONS IN: NAD+ kinase activity, NADH kinase activity; INVOLVED IN: NADP biosynthetic process, response to virus, response to hydrogen peroxide, pyridine nucleotide biosynthetic process, response to ionizing radiation; LOCATED IN: cellular_component unknown; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: ATP-NAD kinase, PpnK-type (InterPro:IPR016064), ATP-NAD/AcoX kinase (InterPro:IPR002504), ATP-NAD kinase, PpnK-type, all-beta (InterPro:IPR017437); BEST Arabidopsis thaliana protein match is: NAD kinase 2 (TAIR:AT1G21640.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

7380191..7384163 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202618.3 → NP_974347.1 NAD kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974347.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q56YN3, Q6TXT3, Q8RX27, Q9LJC5

UniProtKB/TrEMBL

A0A178V8A4, A0A5S9XE72

Conserved Domains (1) summary

PLN02935
Location:23 → 524

PLN02935; Bifunctional NADH kinase/NAD(+) kinase
NM_001338500.1 → NP_001327317.1 NAD kinase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LRY1
NM_001338499.1 → NP_001319603.1 NAD kinase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

F4IWD3
NM_001338501.1 → NP_001327316.1 NAD kinase 1 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LRY0