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    EBS5 HCP-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838406, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EBS5
    Official Full Name
    HCP-like superfamily protein
    Primary source
    TAIR:AT1G18260
    Locus tag
    AT1G18260
    See related
    Araport:AT1G18260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    EMS-mutagenized bri1 suppressor 5; HRD3A; T10O22.22; T10O22_22
    Summary
    Encodes an Arabidopsis homolog of the yeast Hrd3/mammlian Sel1L protein. Involved in ERAD (Endoplasmic reticulum-associated degradation).
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    Genomic context

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    See EBS5 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (6278788..6282144, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Pathogenesis-related thaumatin superfamily protein Neighboring gene zein-binding protein (Protein of unknown function, DUF593) Neighboring gene ketose-bisphosphate aldolase class-II family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance. Liu L, et al. Cell Res, 2011 Jun. PMID 21187857, Free PMC Article
    2. The Arabidopsis homolog of the mammalian OS-9 protein plays a key role in the endoplasmic reticulum-associated degradation of misfolded receptor-like kinases. Su W, et al. Mol Plant, 2012 Jul. PMID 22516478, Free PMC Article
    3. A context-independent N-glycan signal targets the misfolded extracellular domain of Arabidopsis STRUBBELIG to endoplasmic-reticulum-associated degradation. Hüttner S, et al. Biochem J, 2014 Dec 15. PMID 25251695, Free PMC Article
    4. Conserved endoplasmic reticulum-associated degradation system to eliminate mutated receptor-like kinases in Arabidopsis. Su W, et al. Proc Natl Acad Sci U S A, 2011 Jan 11. PMID 21187394, Free PMC Article
    5. EBS7 is a plant-specific component of a highly conserved endoplasmic reticulum-associated degradation system in Arabidopsis. Liu Y, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26371323, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_101684.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ERAD pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ERAD pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 

    General protein information

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    Preferred Names
    HCP-like superfamily protein
    NP_564049.1
    • HCP-like superfamily protein; FUNCTIONS IN: binding; INVOLVED IN: biological_process unknown; LOCATED IN: endoplasmic reticulum, membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Tetratricopeptide-like helical (InterPro:IPR011990), Sel1-like (InterPro:IPR006597); BEST Arabidopsis thaliana protein match is: HCP-like superfamily protein (TAIR:AT1G73570.1); Has 24350 Blast hits to 8436 proteins in 1359 species: Archae - 0; Bacteria - 17163; Metazoa - 848; Fungi - 960; Plants - 547; Viruses - 27; Other Eukaryotes - 4805 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6278788..6282144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101684.4 → NP_564049.1  HCP-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94BN9, Q9LM25
      UniProtKB/TrEMBL
      A0A5S9UZM5, A0A654ECV0
      Conserved Domains (4) summary
      smart00671
      Location:540 → 570
      SEL1; Sel1-like repeats
      COG0790
      Location:226 → 472
      TPR; TPR repeat [Signal transduction mechanisms]
      sd00010
      Location:262 → 291
      SLR; SLR repeat [structural motif]
      pfam08238
      Location:279 → 313
      Sel1; Sel1 repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LM25.1

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