ATARCA Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: ATARCA
Official Full Name: Transducin/WD40 repeat-like superfamily protein
Primary source: TAIR:AT1G18080
Locus tag: AT1G18080
See related: Araport:AT1G18080
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: RACK1A; RACK1A_AT; RECEPTOR FOR ACTIVATED C KINASE 1 A; T10F20.9; WD-40 REPEAT PROTEIN ATARCA
Summary: Encodes the Arabidopsis thaliana homolog of the tobacco WD-40 repeat ArcA gene. Knockout mutants show insensitivity to gibberellin in GA-induced seed germination.
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Genomic context

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See ATARCA in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 2

Sequence:: Chromosome: 1; NC_003070.9 (6222201..6224242)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RACK1 links phyB and BES1 to coordinate brassinosteroid-dependent root meristem development.
Title: RACK1 links phyB and BES1 to coordinate brassinosteroid-dependent root meristem development.
RACK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis.
Title: RACK1A promotes hypocotyl elongation by scaffolding light signaling components in Arabidopsis.
Scaffold protein RACK1A positively regulates leaf senescence by coordinating the EIN3-miR164-ORE1 transcriptional cascade in Arabidopsis.
Title: Scaffold protein RACK1A positively regulates leaf senescence by coordinating the EIN3-miR164-ORE1 transcriptional cascade in Arabidopsis.
down-regulation of auxin signaling through RACK1A induced miR393 biogenesis potentially regulates the Arabidopsis acclimation to salinity.
Title: miR393s regulate salt stress response pathway in Arabidopsis thaliana through scaffold protein RACK1A mediated ABA signaling pathways.
the genes responsible for two additional suppressor mutants of acl5-1 designated sac53-d and sac56-d encode a receptor for activated C kinase 1 (RACK1) homolog and a ribosomal protein L4 (RPL4), respectively
Title: Mutations in ribosomal proteins, RPL4 and RACK1, suppress the phenotype of a thermospermine-deficient mutant of Arabidopsis thaliana.
In total 97 proteins from dehydration, salt stress, ribosomal and photosynthesis pathways are found to potentially interact with RACK1A.
Title: Arabidopsis scaffold protein RACK1A interacts with diverse environmental stress and photosynthesis related proteins.
RACK1 ensures the accumulation and processing of some miRNA precursors, directly interacts with SERRATE and is part of an AGO1 complex
Title: RACK1 scaffold proteins influence miRNA abundance in Arabidopsis.
RACK1A protein can form complexes with the gamma subunit of the signal transducing heterotrimeric G protein.
Title: Arabidopsis thaliana Nudix hydrolase AtNUDT7 forms complexes with the regulatory RACK1A protein and Ggamma subunits of the signal transducing heterotrimeric G protein.
RACK1 may be required for normal production of 60S and 80S ribosomes and that its action in these processes may be regulated by abscissic acid. [RACK1A]
Title: Involvement of Arabidopsis RACK1 in protein translation and its regulation by abscisic acid.
RACK1 genes act redundantly to negatively regulate abscisic acid responses during seed germination and early seedling development.
Title: RACK1 is a negative regulator of ABA responses in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_101670.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables MAP-kinase scaffold activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to abscisic acid stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gibberellin mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of translation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to gibberellin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to glucose	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ribosome biogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosolic ribosome	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Transducin/WD40 repeat-like superfamily protein

NP_173248.1

ATARCA; FUNCTIONS IN: nucleotide binding; INVOLVED IN: response to cadmium ion; LOCATED IN: cytosolic ribosome, chloroplast, heterotrimeric G-protein complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: receptor for activated C kinase 1B (TAIR:AT1G48630.1); Has 86693 Blast hits to 36128 proteins in 955 species: Archae - 98; Bacteria - 10140; Metazoa - 33986; Fungi - 19643; Plants - 11429; Viruses - 3; Other Eukaryotes - 11394 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

6222201..6224242

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_101670.3 → NP_173248.1 Transducin/WD40 repeat-like superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_173248.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C0Z2G7, O24456, Q9LDI1

UniProtKB/TrEMBL

A0A178WHX3, A0A5S9UYG5

Conserved Domains (2) summary

cd00200
Location:7 → 322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:67 → 103

7WD40; WD40 repeat [structural motif]