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    MSH6 MUTS homolog 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MSH6
    Official Full Name
    MUTS homolog 6
    Primary source
    TAIR:AT4G02070
    Locus tag
    AT4G02070
    See related
    Araport:AT4G02070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA MUTS HOMOLOG 6; ATMSH6; MSH6-1; MUTS HOMOLOG 6-1; MUTS homolog 6; MUTS HOMOLOG 6-1; T10M13.8; T10M13_8
    Summary
    encodes a DNA mismatch repair homolog of human MutS gene, MSH6. There are four MutS genes in Arabidopsis, MSH2, MSH3, MSH6, and MSH7, which all act as heterodimers and bind to 51-mer duplexes. MSH2*MSH6 bound the (+T) substrate strongly, (T/G) well, and (+AAG) no better than it did a (T/A) homoduplex.
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    Genomic context

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    See MSH6 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    21
    Sequence:
    Chromosome: 4; NC_003075.7 (905865..913290)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene sugar transporter protein 7 Neighboring gene tRNA-His Neighboring gene Minichromosome maintenance (MCM2/3/5) family protein Neighboring gene RING/FYVE/PHD zinc finger superfamily protein Neighboring gene secretion-associated RAS super family 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant-specific environmental and developmental signals regulate the mismatch repair protein MSH6 in Arabidopsis thaliana. Gonzalez V, et al. Plant Sci, 2024 May. PMID 38401766
    2. Deficiency of the Arabidopsis mismatch repair MSH6 attenuates Pseudomonas syringae invasion. Ramos RS, et al. Plant Sci, 2023 Jul. PMID 37068662
    3. The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana. Gonzalez V, et al. DNA Repair (Amst), 2020 Mar. PMID 31945543
    4. Regulation of plant MSH2 and MSH6 genes in the UV-B-induced DNA damage response. Lario LD, et al. J Exp Bot, 2011 May. PMID 21307385
    5. Arabidopsis MutS homologs-AtMSH2, AtMSH3, AtMSH6, and a novel AtMSH7-form three distinct protein heterodimers with different specificities for mismatched DNA. Culligan KM, et al. Plant Cell, 2000 Jun. PMID 10852942, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant-specific environmental and developmental signals regulate the mismatch repair protein MSH6 in Arabidopsis thaliana.
      Title: Plant-specific environmental and developmental signals regulate the mismatch repair protein MSH6 in Arabidopsis thaliana.
    2. Deficiency of the Arabidopsis mismatch repair MSH6 attenuates Pseudomonas syringae invasion.
      Title: Deficiency of the Arabidopsis mismatch repair MSH6 attenuates Pseudomonas syringae invasion.
    3. The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana.
      Title: The mismatch repair protein MSH6 regulates somatic recombination in Arabidopsis thaliana.
    4. The contribution of MutSalpha (MSH2-MSH6) to ultraviolet-induced DNA lesion repair and cell cycle regulation was investigated.
      Title: Regulation of plant MSH2 and MSH6 genes in the UV-B-induced DNA damage response.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001203727.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within pyrimidine dimer repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    MUTS homolog 6
    NP_001190656.1
    • MUTS homolog 6 (MSH6); FUNCTIONS IN: damaged DNA binding; INVOLVED IN: mismatch repair; LOCATED IN: chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Msh6 (InterPro:IPR017261), DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), Tudor domain (InterPro:IPR002999); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1).
    NP_192116.1
    • MUTS homolog 6 (MSH6); FUNCTIONS IN: damaged DNA binding; INVOLVED IN: mismatch repair; LOCATED IN: chloroplast; EXPRESSED IN: 16 plant structures; EXPRESSED DURING: 8 growth stages; CONTAINS InterPro DOMAIN/s: DNA mismatch repair protein Msh6 (InterPro:IPR017261), DNA mismatch repair protein MutS, clamp (InterPro:IPR007861), DNA mismatch repair protein MutS, connector (InterPro:IPR007860), DNA mismatch repair protein MutS, core (InterPro:IPR007696), DNA mismatch repair protein MutS-like, N-terminal (InterPro:IPR007695), DNA mismatch repair protein MutS, N-terminal (InterPro:IPR016151), DNA mismatch repair protein MutS, C-terminal (InterPro:IPR000432), DNA mismatch repair protein MutS-homologue MSH6 (InterPro:IPR015536), Tudor domain (InterPro:IPR002999); BEST Arabidopsis thaliana protein match is: homolog of DNA mismatch repair protein MSH3 (TAIR:AT4G25540.1); Has 29702 Blast hits to 21889 proteins in 2967 species: Archae - 234; Bacteria - 11721; Metazoa - 3243; Fungi - 2118; Plants - 3658; Viruses - 802; Other Eukaryotes - 7926 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      905865..913290
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_116438.2 → NP_192116.1  MUTS homolog 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_192116.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O04716
      UniProtKB/TrEMBL
      A0A178UWN6, A0A654FL40
      Conserved Domains (2) summary
      COG0249
      Location:376 → 1297
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      cl02573
      Location:124 → 175
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...

    2. NM_001203727.2 → NP_001190656.1  MUTS homolog 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190656.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UWN6, F4JH76
      Conserved Domains (7) summary
      COG0249
      Location:373 → 1294
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam01624
      Location:377 → 493
      MutS_I; MutS domain I
      pfam05188
      Location:502 → 662
      MutS_II; MutS domain II
      pfam05190
      Location:883 → 974
      MutS_IV; MutS family domain IV
      pfam05192
      Location:698 → 834
      MutS_III; MutS domain III
      cl02573
      Location:124 → 175
      TUDOR; Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to ...
      cl21455
      Location:1042 → 1260
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O04716.2

    Gene LinkOut

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