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    FIB2 fibrillarin 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828668, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FIB2
    Official Full Name
    fibrillarin 2
    Primary source
    TAIR:AT4G25630
    Locus tag
    AT4G25630
    See related
    Araport:AT4G25630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFIB2; fibrillarin 2; L73G19.10; L73G19_10
    Summary
    encodes a fibrillarin, a key nucleolar protein in eukaryotes which associates with box C/D small nucleolar RNAs (snoRNAs) directing 2'-O-ribose methylation of the rRNA. This gene also encodes a novel box C/D snoRNA, U60.2f in its fifth intron that accumulates in seedlings and that their targeted residue on the 25 S rRNA is methylated.
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    Genomic context

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    See FIB2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    7
    Sequence:
    Chromosome: 4; NC_003075.7 (13074090..13076432)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Oxoglutarate/iron-dependent oxygenase Neighboring gene C2H2-like zinc finger protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene detoxifying efflux carrier 35 Neighboring gene ACD1-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant viral proteins and fibrillarin: the link to complete the infective cycle. Decle-Carrasco S, et al. Mol Biol Rep, 2021 May. PMID 34036480
    2. Novel Ribonuclease Activity Differs between Fibrillarins from Arabidopsis thaliana. Rodriguez-Corona U, et al. Front Plant Sci, 2017. PMID 29163603, Free PMC Article
    3. Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates. Rakitina DV, et al. Nucleic Acids Res, 2011 Nov 1. PMID 21785141, Free PMC Article
    4. Arabidopsis ribosomal proteins RPL23aA and RPL23aB are differentially targeted to the nucleolus and are disparately required for normal development. Degenhardt RF, et al. Plant Physiol, 2008 May. PMID 18322146, Free PMC Article
    5. Fibrillarin genes encode both a conserved nucleolar protein and a novel small nucleolar RNA involved in ribosomal RNA methylation in Arabidopsis thaliana. Barneche F, et al. J Biol Chem, 2000 Sep 1. PMID 10829025

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Plant viral proteins and fibrillarin: the link to complete the infective cycle.
      Title: Plant viral proteins and fibrillarin: the link to complete the infective cycle.
    2. ELENA1 can dissociate the FIB2/MED19a complex and release FIB2 from PR1 promoter to enhance PR1 expression.
      Title: ELF18-INDUCED LONG NONCODING RNA 1 evicts fibrillarin from mediator subunit to enhance PATHOGENESIS-RELATED GENE 1 (PR1) expression.
    3. The data indicates that AtFib2 possesses two RNA-binding sites in the central (138-179 amino acids) and C-terminal (225-281 amino acids) parts of the protein, respectively.
      Title: Two RNA-binding sites in plant fibrillarin provide interactions with various RNA substrates.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_118695.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA methylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within rRNA processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    fibrillarin 2
    NP_567724.1
    • fibrillarin 2 (FIB2); FUNCTIONS IN: snoRNA binding; INVOLVED IN: response to salt stress, RNA methylation, rRNA processing; LOCATED IN: nucleolus; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fibrillarin (InterPro:IPR000692); BEST Arabidopsis thaliana protein match is: fibrillarin 1 (TAIR:AT5G52470.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      13074090..13076432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118695.4 → NP_567724.1  fibrillarin 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567724.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AH9, Q9SZZ1
      UniProtKB/TrEMBL
      A0A178UZ20, A0A5S9XW69
      Conserved Domains (1) summary
      PTZ00146
      Location:75 → 315
      PTZ00146; fibrillarin; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AH9.2

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