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    PANK2 pantothenate kinase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 829351, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PANK2
    Official Full Name
    pantothenate kinase 2
    Primary source
    TAIR:AT4G32180
    Locus tag
    AT4G32180
    See related
    Araport:AT4G32180
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPANK2; F10M6.180; F10M6_180; pantothenate kinase 2
    Summary
    Encodes a protein with pantothenate kinase activity.
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    Genomic context

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    See PANK2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    22
    Sequence:
    Chromosome: 4; NC_003075.7 (15537559..15543954, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene Phox (PX) domain-containing protein Neighboring gene cytochrome P450, family 96, subfamily A, polypeptide 2 Neighboring gene PNAS-3-like protein Neighboring gene Myosin heavy chain-related protein Neighboring gene DNA-binding HORMA family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Plant coenzyme A biosynthesis: characterization of two pantothenate kinases from Arabidopsis. Tilton GB, et al. Plant Mol Biol, 2006 Jul. PMID 16897480
    2. Proteomic profiling of tandem affinity purified 14-3-3 protein complexes in Arabidopsis thaliana. Chang IF, et al. Proteomics, 2009 Jun. PMID 19452453, Free PMC Article
    3. Identification of ubiquitinated proteins in Arabidopsis. Manzano C, et al. Plant Mol Biol, 2008 Sep. PMID 18535787
    4. 14-3-3 proteins fine-tune plant nutrient metabolism. Shin R, et al. FEBS Lett, 2011 Jan 3. PMID 21094157
    5. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036691.1
    NM_001125620.1
    NM_119370.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables pantothenate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pantothenate kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables pantothenate kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in coenzyme A biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    pantothenate kinase 2
    NP_001031768.1
    • pantothenate kinase 2 (PANK2); FUNCTIONS IN: protein binding, pantothenate kinase activity; INVOLVED IN: coenzyme A biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Fumble (InterPro:IPR011602), Domain of unknown function DUF89 (InterPro:IPR002791), Pantothenate kinase, acetyl-CoA regulated, two-domain type (InterPro:IPR015844), Eukaryotic pantothenate kinase (InterPro:IPR004567); BEST Arabidopsis thaliana protein match is: pantothenate kinase 1 (TAIR:AT1G60440.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001119092.1
    • pantothenate kinase 2 (PANK2); FUNCTIONS IN: protein binding, pantothenate kinase activity; INVOLVED IN: coenzyme A biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Fumble (InterPro:IPR011602), Domain of unknown function DUF89 (InterPro:IPR002791), Pantothenate kinase, acetyl-CoA regulated, two-domain type (InterPro:IPR015844), Eukaryotic pantothenate kinase (InterPro:IPR004567); BEST Arabidopsis thaliana protein match is: pantothenate kinase 1 (TAIR:AT1G60440.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_194945.3
    • pantothenate kinase 2 (PANK2); FUNCTIONS IN: protein binding, pantothenate kinase activity; INVOLVED IN: coenzyme A biosynthetic process; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Fumble (InterPro:IPR011602), Domain of unknown function DUF89 (InterPro:IPR002791), Pantothenate kinase, acetyl-CoA regulated, two-domain type (InterPro:IPR015844), Eukaryotic pantothenate kinase (InterPro:IPR004567); BEST Arabidopsis thaliana protein match is: pantothenate kinase 1 (TAIR:AT1G60440.1); Has 1440 Blast hits to 1407 proteins in 439 species: Archae - 13; Bacteria - 450; Metazoa - 360; Fungi - 145; Plants - 175; Viruses - 0; Other Eukaryotes - 297 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      15537559..15543954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_119370.5 → NP_194945.3  pantothenate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_194945.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O49372, O49374, Q8L5Y9
      UniProtKB/TrEMBL
      A0A178V4D0, A0A5S9XYA6, A0A7G2F2L1
      Conserved Domains (1) summary
      PLN02902
      Location:25 → 901
      PLN02902; pantothenate kinase

    2. NM_001036691.1 → NP_001031768.1  pantothenate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2L1, F4JTJ6
      Conserved Domains (3) summary
      PLN02902
      Location:25 → 782
      PLN02902; pantothenate kinase
      cl15397
      Location:572 → 777
      DUF89; Protein of unknown function DUF89
      cl17037
      Location:64 → 462
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    3. NM_001125620.1 → NP_001119092.1  pantothenate kinase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001119092.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2F2L1, F4JTJ6
      Conserved Domains (3) summary
      PLN02902
      Location:25 → 782
      PLN02902; pantothenate kinase
      cl15397
      Location:572 → 777
      DUF89; Protein of unknown function DUF89
      cl17037
      Location:64 → 462
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8L5Y9.2

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