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    SNRK2.2 SNF1-related protein kinase 2.2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824214, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SNRK2.2
    Official Full Name
    SNF1-related protein kinase 2.2
    Primary source
    TAIR:AT3G50500
    Locus tag
    AT3G50500
    See related
    Araport:AT3G50500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 2-2; SNF1-related protein kinase 2.2; SNRK2-2; SPK-2-2; SRK2D
    Summary
    encodes a member of SNF1-related protein kinases (SnRK2) whose activity is activated by ionic (salt) and non-ionic (mannitol) osmotic stress. Enzyme involved in the ABA signaling during seed germination, dormancy and seedling growth.
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    Genomic context

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    See SNRK2.2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (18741444..18744174, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene homolog of RPW8 4 Neighboring gene pseudo Neighboring gene tRNA-Glu Neighboring gene LOB domain-containing protein 28

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of two protein kinases required for abscisic acid regulation of seed germination, root growth, and gene expression in Arabidopsis. Fujii H, et al. Plant Cell, 2007 Feb. PMID 17307925, Free PMC Article
    2. Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins. Wang P, et al. Plant Signal Behav, 2015. PMID 26024299, Free PMC Article
    3. Four Arabidopsis AREB/ABF transcription factors function predominantly in gene expression downstream of SnRK2 kinases in abscisic acid signalling in response to osmotic stress. Yoshida T, et al. Plant Cell Environ, 2015 Jan. PMID 24738645, Free PMC Article
    4. Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy. Nakashima K, et al. Plant Cell Physiol, 2009 Jul. PMID 19541597
    5. Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis. Fujita Y, et al. Plant Cell Physiol, 2009 Dec. PMID 19880399

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recruitment of HAB1 and SnRK2.2 by C2-domain protein CAR1 in plasma membrane ABA signaling.
      Title: Recruitment of HAB1 and SnRK2.2 by C2-domain protein CAR1 in plasma membrane ABA signaling.
    2. More detailed analyses suggested an interaction network between abscissic acid-activated SnRK2-type protein kinases and several PP2A-type protein phosphatase regulatory subunits.
      Title: Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses.
    3. Rav1 is phosphorylated by SnRK2.2 kinase.
      Title: Arabidopsis RAV1 transcription factor, phosphorylated by SnRK2 kinases, regulates the expression of ABI3, ABI4, and ABI5 during seed germination and early seedling development.
    4. Nitric oxide negatively regulates abscissic acid signaling in germination and early seedling growth through S-nitrosylation of SnRK2.2 and SnRK2.3.
      Title: Nitric oxide suppresses the inhibitory effect of abscisic acid on seed germination by S-nitrosylation of SnRK2 proteins.
    5. The four AREB/ABFs are the predominant transcription factors downstream of SRK2D/E/I in abscisic acid (ABA) signalling in response to osmotic stress during vegetative growth.
      Title: Four Arabidopsis AREB/ABF transcription factors function predominantly in gene expression downstream of SnRK2 kinases in abscisic acid signalling in response to osmotic stress.
    6. Data show that the decuple mutant snrk2.1/2/3/4/5/6/7/8/9/10 grew poorly under hyperosmotic stress conditions but was similar to the wild type in culture media in the absence of osmotic stress.
      Title: Arabidopsis decuple mutant reveals the importance of SnRK2 kinases in osmotic stress responses in vivo.
    7. SRK2D, SRK2E and SRK2I protein kinases involved in ABA signaling are essential for the control of seed development and dormancy.
      Title: Three Arabidopsis SnRK2 protein kinases, SRK2D/SnRK2.2, SRK2E/SnRK2.6/OST1 and SRK2I/SnRK2.3, involved in ABA signaling are essential for the control of seed development and dormancy.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001203118.1
    NM_114910.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of abscisic acid-activated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of seed germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to abscisic acid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to gibberellin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to salt stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SNF1-related protein kinase 2.2
    NP_001190047.1
    • SNF1-related protein kinase 2.2 (SNRK2.2); CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: sucrose nonfermenting 1(SNF1)-related protein kinase 2.3 (TAIR:AT5G66880.1).
    NP_190619.1
    • SNF1-related protein kinase 2.2 (SNRK2.2); FUNCTIONS IN: protein kinase activity, kinase activity; INVOLVED IN: in 7 processes; LOCATED IN: cytosol, nucleus, cytoplasm; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Serine/threonine-protein kinase-like, plant (InterPro:IPR015740); BEST Arabidopsis thaliana protein match is: sucrose nonfermenting 1(SNF1)-related protein kinase 2.3 (TAIR:AT5G66880.1); Has 115487 Blast hits to 113731 proteins in 3342 species: Archae - 110; Bacteria - 13353; Metazoa - 42986; Fungi - 12252; Plants - 26670; Viruses - 490; Other Eukaryotes - 19626 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      18741444..18744174 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114910.3 → NP_190619.1  SNF1-related protein kinase 2.2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190619.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q39192, Q8LAA1, Q93ZE6
      UniProtKB/TrEMBL
      A0A178VHA9, A0A5S9XJR5, A0A7G2EU24
      Conserved Domains (1) summary
      cd14665
      Location:22 → 278
      STKc_SnRK2-3; Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3

    2. NM_001203118.1 → NP_001190047.1  SNF1-related protein kinase 2.2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A7G2EU24, F4J0N1
      Conserved Domains (2) summary
      smart00220
      Location:23 → 286
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:22 → 285
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q39192.1

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