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    PIP5K4 phosphatidyl inositol monophosphate 5 kinase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824863, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PIP5K4
    Official Full Name
    phosphatidyl inositol monophosphate 5 kinase 4
    Primary source
    TAIR:AT3G56960
    Locus tag
    AT3G56960
    See related
    Araport:AT3G56960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    phosphatidyl inositol monophosphate 5 kinase 4; T8M16.6
    Summary
    Encodes a protein with phosphatidylinositol-4-phosphate 5-kinase activity that plays a role in pollen tip growth. The enzyme localizes to the apical plasma membrane and adjacent cytosolic region of pollen tubes. Overexpression of this gene leads to increased deposition of pectin in the cell wall at the tip of the pollen tube and causes altered pollen tube morphology.
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    Genomic context

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    See PIP5K4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (21079957..21084420)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene dicarboxylate diiron protein, putative (Crd1) Neighboring gene small and basic intrinsic protein 2;1 Neighboring gene ncRNA Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene basic helix-loop-helix (bHLH) DNA-binding superfamily protein Neighboring gene embryo sac development arrest 7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Arabidopsis phosphatidylinositol-4-monophosphate 5-kinase 4 regulates pollen tube growth and polarity by modulating membrane recycling. Sousa E, et al. Plant Cell, 2008 Nov. PMID 19033528, Free PMC Article
    2. Phosphatidylinositol 4,5-bisphosphate is important for stomatal opening. Lee Y, et al. Plant J, 2007 Dec. PMID 17883374
    3. Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana. Wada Y, et al. Plant J, 2015 Feb. PMID 25477067
    4. Type B phosphatidylinositol-4-phosphate 5-kinases mediate Arabidopsis and Nicotiana tabacum pollen tube growth by regulating apical pectin secretion. Ischebeck T, et al. Plant Cell, 2008 Dec. PMID 19060112, Free PMC Article
    5. The Arabidopsis Phosphatidylinositol Phosphate 5-Kinase PIP5K3 is a key regulator of root hair tip growth. Kusano H, et al. Plant Cell, 2008 Feb. PMID 18281506, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PIP5K4 plays a crucial role in regulating the polarity of pollen tubes by modulating membrane recycling.
      Title: Arabidopsis phosphatidylinositol-4-monophosphate 5-kinase 4 regulates pollen tube growth and polarity by modulating membrane recycling.
    2. PIP5K4 produces PtdIns(4,5)P(2) in irradiated guard cells, inhibiting anion channels to allow full stomatal opening.
      Title: Phosphatidylinositol 4,5-bisphosphate is important for stomatal opening.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001339834.1
    NM_115555.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within establishment of tissue polarity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within phosphatidylinositol metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within plant-type cell wall modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen germination IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within pollen tube growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within stomatal movement IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in pollen tube IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidyl inositol monophosphate 5 kinase 4
    NP_001319773.1
    • phosphatidyl inositol monophosphate 5 kinase 4 (PIP5K4); CONTAINS InterPro DOMAIN/s: Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup (InterPro:IPR016034), Phosphatidylinositol-4-phosphate 5-kinase, plant (InterPro:IPR017163), MORN motif (InterPro:IPR003409), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: phosphatidylinositol- 4-phosphate 5-kinase 5 (TAIR:AT2G41210.1); Has 27454 Blast hits to 7705 proteins in 602 species: Archae - 2; Bacteria - 4208; Metazoa - 4073; Fungi - 443; Plants - 2320; Viruses - 0; Other Eukaryotes - 16408 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21079957..21084420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339834.1 → NP_001319773.1  phosphatidyl inositol monophosphate 5 kinase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1K2
      UniProtKB/TrEMBL
      A0A5S9XLP2

    2. NM_115555.2 → NP_191255.1  phosphatidyl inositol monophosphate 5 kinase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191255.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9M1K2
      UniProtKB/TrEMBL
      A0A5S9XLP2
      Conserved Domains (4) summary
      smart00698
      Location:144 → 165
      MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases
      smart00330
      Location:417 → 775
      PIPKc; Phosphatidylinositol phosphate kinases
      PLN03185
      Location:68 → 775
      PLN03185; phosphatidylinositol phosphate kinase; Provisional
      pfam02493
      Location:77 → 99
      MORN; MORN repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9M1K2.1

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