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    PAO3 polyamine oxidase 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825074, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PAO3
    Official Full Name
    polyamine oxidase 3
    Primary source
    TAIR:AT3G59050
    Locus tag
    AT3G59050
    See related
    Araport:AT3G59050
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATPAO3; polyamine oxidase 3
    Summary
    Encodes a polyamine oxidase.
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    Genomic context

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    See PAO3 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (21824696..21827509, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene MATE efflux family protein Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene ncRNA Neighboring gene phytochrome interacting factor 3-like 6 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. GUS Reporter-Aided Promoter Deletion Analysis of A. thaliana POLYAMINE OXIDASE 3. Podia V, et al. Int J Mol Sci, 2023 Jan 24. PMID 36768644, Free PMC Article
    2. Spermidine oxidase-derived H₂O₂ regulates pollen plasma membrane hyperpolarization-activated Ca(2+) -permeable channels and pollen tube growth. Wu J, et al. Plant J, 2010 Sep. PMID 20626657
    3. Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis. Moschou PN, et al. Plant Physiol, 2008 Aug. PMID 18583528, Free PMC Article
    4. Characterization of five polyamine oxidase isoforms in Arabidopsis thaliana. Takahashi Y, et al. Plant Cell Rep, 2010 Sep. PMID 20532512
    5. An abscisic acid-responsive protein interaction network for sucrose non-fermenting related kinase1 in abiotic stress response. Carianopol CS, et al. Commun Biol, 2020 Mar 26. PMID 32218501, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pollen from two mutants lacking expression of AtPAO3 was unable to induce the opening of the Ca(2+) -permeable channels in the presence of Spd, resulting in reduced pollen tube growth and seed number.
      Title: Spermidine oxidase-derived H₂O₂ regulates pollen plasma membrane hyperpolarization-activated Ca(2+) -permeable channels and pollen tube growth.
    2. AtPAO3 catalyzes the sequential conversion/oxidation of spermine to spermidine, and of spermidine to putrescine, thus exhibiting functional homology to the mammalian PAOs.
      Title: Bridging the gap between plant and mammalian polyamine catabolism: a novel peroxisomal polyamine oxidase responsible for a full back-conversion pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: c21827383-21827177 AT3G59050.uORF1
    NM_115767.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables N(1)-acetylpolyamine oxidase (3-acetamidopropanal-forming) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polyamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spermine oxidase (propane-1,3-diamine-forming) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables spermine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within polyamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in spermidine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    polyamine oxidase 3
    NP_191464.1
    • polyamine oxidase 3 (PAO3); CONTAINS InterPro DOMAIN/s: Amine oxidase (InterPro:IPR002937), Flavin-containing amine oxidase (InterPro:IPR001613); BEST Arabidopsis thaliana protein match is: polyamine oxidase 2 (TAIR:AT2G43020.1); Has 6641 Blast hits to 6191 proteins in 1102 species: Archae - 131; Bacteria - 2618; Metazoa - 1408; Fungi - 589; Plants - 766; Viruses - 0; Other Eukaryotes - 1129 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21824696..21827509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115767.3 → NP_191464.1  polyamine oxidase 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191464.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LE44, Q9LYT1
      UniProtKB/TrEMBL
      A0A5S9XM40, A0A654FJ44
      Conserved Domains (1) summary
      PLN02268
      Location:29 → 463
      PLN02268; probable polyamine oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LYT1.1

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